Literature DB >> 22542807

Statins and cancer: current and future prospects.

Maja Osmak1.   

Abstract

Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects beyond cholesterol reduction, including anticancer activity. This review presents the effects of statins in vitro and their possible molecular anticancer mechanisms and critically discusses the data regarding the role of statins in cancer prevention. Finally, this review focuses on the use of statins combined with other chemotherapeutics to increase the effectiveness of cancer treatments. Despite rare and inconclusive clinical data, the preclinical results strongly suggest that such combined treatment could be a promising new strategy for the treatment of certain tumor types.
Copyright © 2012. Published by Elsevier Ireland Ltd.

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Year:  2012        PMID： 22542807     DOI： 10.1016/j.canlet.2012.04.011

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  67 in total

1.  Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase.

Authors:  Nicolle V Fernandes; Hoda Yeganehjoo; Rajasekhar Katuru; Russell A DeBose-Boyd; Lindsey L Morris; Renee Michon; Zhi-Ling Yu; Huanbiao Mo
Journal:  Exp Biol Med (Maywood)       Date:  2013-09-04

2.  Effects of statins on the risk of hepatocellular carcinoma.

Authors:  Pejman G Mansourian; Masato Yoneda; M Krishna Rao; Fernando J Martinez; Emmanuel Thomas; Eugene R Schiff
Journal:  Gastroenterol Hepatol (N Y)       Date:  2014-07

3.  Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.

Authors:  Svenja Nölting; Alessio Giubellino; Yasin Tayem; Karen Young; Michael Lauseker; Petra Bullova; Jan Schovanek; Miriam Anver; Stephanie Fliedner; Márta Korbonits; Burkhard Göke; George Vlotides; Ashley Grossman; Karel Pacak
Journal:  Endocrinology       Date:  2014-04-24       Impact factor: 4.736

Review 4.  The effect of statins on cancer cells--review.

Authors:  Lucyna Matusewicz; Justyna Meissner; Monika Toporkiewicz; Aleksander F Sikorski
Journal:  Tumour Biol       Date:  2015-05-23

Review 5.  Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.

Authors:  Julian Swierczynski; Areta Hebanowska; Tomasz Sledzinski
Journal:  World J Gastroenterol       Date:  2014-03-07       Impact factor: 5.742

6.  Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.

Authors:  Hongyuan Zhang; Qingxia Wei; Hidetoshi Tsushima; Vijitha Puviindran; Yuning J Tang; Sinthu Pathmanapan; Raymond Poon; Eyal Ramu; Mushriq Al-Jazrawe; Jay Wunder; Benjamin A Alman
Journal:  JCI Insight       Date:  2019-04-30

7.  Association of Statin Use and High Serum Cholesterol Levels With Risk of Primary Open-Angle Glaucoma.

Authors:  Jae H Kang; Tahani Boumenna; Joshua D Stein; Anthony Khawaja; Bernard A Rosner; Janey L Wiggs; Louis R Pasquale
Journal:  JAMA Ophthalmol       Date:  2019-07-01       Impact factor: 7.389

8.  Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation.

Authors:  Chih-Kai Hsu; Chih-Chung Lin; Li-Der Hsiao; Chuen-Mao Yang
Journal:  Br J Pharmacol       Date:  2015-10-23       Impact factor: 8.739

9.  Metformin use and its effect on gastric cancer in patients with type 2 diabetes: A systematic review of observational studies.

Authors:  Peiwen Li; Cong Zhang; Peng Gao; Xiaowan Chen; Bin Ma; Dehao Yu; Yongxi Song; Zhenning Wang
Journal:  Oncol Lett       Date:  2017-11-08       Impact factor: 2.967

10.  Statins impair glucose uptake in tumor cells.

Authors:  Shanmugasundaram Ganapathy-Kanniappan; Rani Kunjithapatham; Jean-Francois H Geschwind
Journal:  Cancer Biol Ther       Date:  2012-12-19       Impact factor: 4.742
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