BACKGROUND: Epidemiologic observations have linked healthy dietary patterns to improved kidney function. STUDY DESIGN: We assessed the effects of the Mediterranean diet (MedDiet) on kidney function in both a cross-sectional assessment and after a 1-year intervention in a cohort of the PREDIMED (Prevención con Dieta Mediterránea) Study, a multicenter 3-arm randomized clinical trial to determine the efficacy of the MedDiet on primary cardiovascular prevention. SETTING & PARTICIPANTS: Community-dwelling men aged 55-80 years and women aged 60-80 years at high risk of cardiovascular disease from Reus, Spain. INTERVENTION: Participants were randomly assigned to 3 ad libitum diets: a MedDiet supplemented with virgin olive oil (MedDiet + olive oil), a MedDiet supplemented with mixed nuts (MedDiet + nuts), or a control low-fat diet. OUTCOMES: Estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (ACR). MEASUREMENTS: Nutrient intake, adherence to the MedDiet, lifestyle variables, cardiovascular risk factors, serum urea and creatinine concentrations, eGFR, and urinary ACR were evaluated at baseline and after intervention for 1 year. RESULTS:Baseline kidney function markers were similar across quartiles of adherence to the MedDiet in 785 participants (55% women; mean age, 67 years). After a 1-year intervention in 665 participants, the 3 dietary approaches were associated with improved kidney function, with similar average increases in eGFR (4.7 [95% CI, 3.2-6.2], 3.5 [95% CI, 1.9-5.0], and 4.1 [95% CI, 2.8-5.5] mL/min/1.73 m(2) for the MedDiet + olive oil, MedDiet + nuts, and control groups, respectively [P < 0.001 vs baseline for each; P = 0.9 for differences among groups]), but no changes in ACRs after adjustment for various confounders. LIMITATIONS: Generalization of results to other age groups or ethnicities. GFR was not directly measured. CONCLUSIONS: The results do not support the notion that the MedDiet has a beneficial effect on kidney function over and above that of advice for a low-fat diet in elderly individuals at high cardiovascular risk.
RCT Entities:
BACKGROUND: Epidemiologic observations have linked healthy dietary patterns to improved kidney function. STUDY DESIGN: We assessed the effects of the Mediterranean diet (MedDiet) on kidney function in both a cross-sectional assessment and after a 1-year intervention in a cohort of the PREDIMED (Prevención con Dieta Mediterránea) Study, a multicenter 3-arm randomized clinical trial to determine the efficacy of the MedDiet on primary cardiovascular prevention. SETTING & PARTICIPANTS: Community-dwelling men aged 55-80 years and women aged 60-80 years at high risk of cardiovascular disease from Reus, Spain. INTERVENTION: Participants were randomly assigned to 3 ad libitum diets: a MedDiet supplemented with virgin olive oil (MedDiet + olive oil), a MedDiet supplemented with mixed nuts (MedDiet + nuts), or a control low-fat diet. OUTCOMES: Estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (ACR). MEASUREMENTS: Nutrient intake, adherence to the MedDiet, lifestyle variables, cardiovascular risk factors, serum urea and creatinine concentrations, eGFR, and urinary ACR were evaluated at baseline and after intervention for 1 year. RESULTS: Baseline kidney function markers were similar across quartiles of adherence to the MedDiet in 785 participants (55% women; mean age, 67 years). After a 1-year intervention in 665 participants, the 3 dietary approaches were associated with improved kidney function, with similar average increases in eGFR (4.7 [95% CI, 3.2-6.2], 3.5 [95% CI, 1.9-5.0], and 4.1 [95% CI, 2.8-5.5] mL/min/1.73 m(2) for the MedDiet + olive oil, MedDiet + nuts, and control groups, respectively [P < 0.001 vs baseline for each; P = 0.9 for differences among groups]), but no changes in ACRs after adjustment for various confounders. LIMITATIONS: Generalization of results to other age groups or ethnicities. GFR was not directly measured. CONCLUSIONS: The results do not support the notion that the MedDiet has a beneficial effect on kidney function over and above that of advice for a low-fat diet in elderly individuals at high cardiovascular risk.
Authors: Xiaoyan Huang; José Juan Jiménez-Moleón; Bengt Lindholm; Tommy Cederholm; Johan Arnlöv; Ulf Risérus; Per Sjögren; Juan Jesús Carrero Journal: Clin J Am Soc Nephrol Date: 2013-06-06 Impact factor: 8.237
Authors: Minesh Khatri; Yeseon P Moon; Nikolaos Scarmeas; Yian Gu; Hannah Gardener; Ken Cheung; Clinton B Wright; Ralph L Sacco; Thomas L Nickolas; Mitchell S V Elkind Journal: Clin J Am Soc Nephrol Date: 2014-10-30 Impact factor: 8.237
Authors: Cristina Valle-Hita; Andrés Díaz-López; Nerea Becerra-Tomás; Miguel A Martínez-González; Verónica Ruiz García; Dolores Corella; Albert Goday; J Alfredo Martínez; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J Tinahones; José Lapetra; Luís Serra-Majem; Naomi Cano-Ibáñez; Josep A Tur; María Rubín-García; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Sebastian Mas Fontao; Lidia Daimiel; Emilio Ros; Estefania Toledo; José V Sorlí; C Roca; Iztiar Abete; Anai Moreno-Rodriguez; Edelys Crespo-Oliva; Inmaculada Candela-García; Marga Morey; Antonio Garcia-Rios; Rosa Casas; Jose Carlos Fernandez-Garcia; José Manuel Santos-Lozano; Javier Diez-Espino; Carolina Ortega-Azorín; M Comas; M Angeles Zulet; Carolina Sorto-Sanchez; Miguel Ruiz-Canela; Montse Fitó; Jordi Salas-Salvadó; Nancy Babio Journal: Eur J Nutr Date: 2022-04-02 Impact factor: 4.865
Authors: Lee Hooper; Nicole Martin; Oluseyi F Jimoh; Christian Kirk; Eve Foster; Asmaa S Abdelhamid Journal: Cochrane Database Syst Rev Date: 2020-08-21
Authors: Lee Hooper; Nicole Martin; Oluseyi F Jimoh; Christian Kirk; Eve Foster; Asmaa S Abdelhamid Journal: Cochrane Database Syst Rev Date: 2020-05-19
Authors: Emily A Hu; Josef Coresh; Cheryl A M Anderson; Lawrence J Appel; Morgan E Grams; Deidra C Crews; Katherine T Mills; Jiang He; Julia Scialla; Mahboob Rahman; Sankar D Navaneethan; James P Lash; Ana C Ricardo; Harold I Feldman; Matthew R Weir; Haochang Shou; Casey M Rebholz Journal: Am J Kidney Dis Date: 2020-08-05 Impact factor: 8.860