| Literature DB >> 22541561 |
Han Zhao1, Jianfeng Xu, Haobo Zhang, Jielin Sun, Yingpu Sun, Zhong Wang, Jiayin Liu, Qiang Ding, Shaoming Lu, Rong Shi, Li You, Yingying Qin, Xiaoming Zhao, Xiaoling Lin, Xiao Li, Junjie Feng, Li Wang, Jeffrey M Trent, Chengyan Xu, Ying Gao, Bo Zhang, Xuan Gao, Jingmei Hu, Hong Chen, Guangyu Li, Junzhao Zhao, Shuhua Zou, Hong Jiang, Cuifang Hao, Yueran Zhao, Jinglong Ma, S Lilly Zheng, Zi-Jiang Chen.
Abstract
A genome-wide association study of Han Chinese subjects was conducted to identify genetic susceptibility loci for nonobstructive azoospermia (NOA). In the discovery stage, 802 azoospermia cases and 1,863 controls were screened for genetic variants in the genome. Promising SNPs were subsequently confirmed in two independent sets of subjects: 818 azoospermia cases and 1,755 controls from northern China, and 606 azoospermia cases and 958 controls from central and southern China. We detected variants at human leukocyte antigen (HLA) regions that were independently associated with NOA (HLA-DRA, rs3129878, p(combine) = 3.70 × 10(-16), odds ratio [OR] = 1.37; C6orf10 and BTNL2, rs498422, p(combine) = 2.43 × 10(-12), OR = 1.42). These findings provide additional insight into the pathogenesis of NOA.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22541561 PMCID： PMC3376492 DOI： 10.1016/j.ajhg.2012.04.001
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025