Literature DB >> 22540882

Supramolecular polymers as dynamic multicomponent cellular uptake carriers.

Katja Petkau-Milroy1, Michael H Sonntag, Arthur H A M van Onzen, Luc Brunsveld.   

Abstract

Supramolecular synthesis represents a flexible approach to the generation of dynamic multicomponent materials with tunable properties. Here, cellular uptake systems based on dynamic supramolecular copolymers have been developed using a combination of differently functionalized discotic molecules. Discotics featuring peripheral amine functionalities that endow the supramolecular polymer with cellular uptake capabilities were readily synthesized. This enabled the uptake of otherwise cell-impermeable discotics via cotransport as a function of supramolecular coassembly. Dynamic multicomponent and multifunctional supramolecular polymers represent a novel and unique platform for modular cellular uptake systems.

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Year:  2012        PMID： 22540882     DOI： 10.1021/ja3029075

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  9 in total

1.  Spatiotemporal control and superselectivity in supramolecular polymers using multivalency.

Authors:  Lorenzo Albertazzi; Francisco J Martinez-Veracoechea; Christianus M A Leenders; Ilja K Voets; Daan Frenkel; E W Meijer
Journal:  Proc Natl Acad Sci U S A       Date:  2013-07-08       Impact factor: 11.205

2.  Multivalent protein assembly using monovalent self-assembling building blocks.

Authors:  Katja Petkau-Milroy; Michael H Sonntag; Alexander Colditz; Luc Brunsveld
Journal:  Int J Mol Sci       Date:  2013-10-22       Impact factor: 5.923

3.  Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.

Authors:  Sam van Dun; Jurgen Schill; Lech-Gustav Milroy; Luc Brunsveld
Journal:  Chemistry       Date:  2018-10-11       Impact factor: 5.236

4.  Facilitating functionalization of benzene-1,3,5-tricarboxamides by switching amide connectivity.

Authors:  Sandra M C Schoenmakers; Bart W L van den Bersselaar; Shikha Dhiman; Lu Su; Anja R A Palmans
Journal:  Org Biomol Chem       Date:  2021-10-06       Impact factor: 3.876

5.  Elucidating dynamic behavior of synthetic supramolecular polymers in water by hydrogen/deuterium exchange mass spectrometry.

Authors:  Xianwen Lou; Sandra M C Schoenmakers; Joost L J van Dongen; Miguel Garcia-Iglesias; Nicolás M Casellas; Marcos Fernández-Castaño Romera; Rint P Sijbesma; E W Meijer; Anja R A Palmans
Journal:  J Polym Sci (2020)       Date:  2021-02-21

6.  Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires.

Authors:  Miguel Ángel Alemán García; Eva Magdalena Estirado; Lech-Gustav Milroy; Luc Brunsveld
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-23       Impact factor: 15.336

7.  Polymorphism in Benzene-1,3,5-tricarboxamide Supramolecular Assemblies in Water: A Subtle Trade-off between Structure and Dynamics.

Authors:  Nicholas M Matsumoto; René P M Lafleur; Xianwen Lou; Kuo-Chih Shih; Sjors P W Wijnands; Clément Guibert; Johannes W A M van Rosendaal; Ilja K Voets; Anja R A Palmans; Yao Lin; E W Meijer
Journal:  J Am Chem Soc       Date:  2018-10-08       Impact factor: 15.419

8.  Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms.

Authors:  Eva Magdalena Estirado; Miguel Angel Aleman Garcia; Jurgen Schill; Luc Brunsveld
Journal:  J Am Chem Soc       Date:  2019-10-31       Impact factor: 15.419

9.  Supramolecular caging for cytosolic delivery of anionic probes.

Authors:  Héctor Fernández-Caro; Irene Lostalé-Seijo; Miguel Martínez-Calvo; Jesús Mosquera; José L Mascareñas; Javier Montenegro
Journal:  Chem Sci       Date:  2019-08-20       Impact factor: 9.825
  9 in total

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