Literature DB >> 22540426

A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma.

Annette J Vangsted1, Kaspar R Nielsen, Tobias W Klausen, Einar Haukaas, Anne Tjønneland, Ulla Vogel.   

Abstract

The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.
© 2012 Blackwell Publishing Ltd.

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Year:  2012        PMID： 22540426     DOI： 10.1111/j.1365-2141.2012.09141.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  12 in total

1.  NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis.

Authors:  Linlin Xu; Shaoyi Huang; Wei Chen; Zhichun Song; Shu Cai
Journal:  Tumour Biol       Date:  2014-02-16

2.  Racial/ethnic disparities in inflammatory gene single-nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis.

Authors:  Qiuling Shi; Xin Shelley Wang; Guojun Li; Nina D Shah; Robert Z Orlowski; Loretta A Williams; Tito R Mendoza; Charles S Cleeland
Journal:  Cancer       Date:  2014-12-02       Impact factor: 6.860

3.  Deploying myeloid cells against myeloma.

Authors:  Jeffrey L Jensen; Chelsea Hope; Fotis Asimakopoulos
Journal:  Oncoimmunology       Date:  2015-12-10       Impact factor: 8.110

Review 4.  An updated meta-analysis of 37 case-control studies on the association between NFKB1 -94ins/del ATTG promoter polymorphism and cancer susceptibility.

Authors:  Yi-Qiao Luo; Duan Wang; Teng Gong; Jiang Zhu
Journal:  Oncotarget       Date:  2016-09-06

5.  Toll-like receptor 4 rs11536889 is associated with angiographic extent and severity of coronary artery disease in a Chinese population.

Authors:  Dandan Sun; Yupeng Wu; Honghu Wang; Hong Yan; Wen Liu; Jun Yang
Journal:  Oncotarget       Date:  2017-01-10

Review 6.  NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies.

Authors:  Wen Fu; Zhen-Jian Zhuo; Yung-Chang Chen; Jinhong Zhu; Zhang Zhao; Wei Jia; Jin-Hua Hu; Kai Fu; Shi-Bo Zhu; Jing He; Guo-Chang Liu
Journal:  Oncotarget       Date:  2017-02-07

7.  Interactions between diet, lifestyle and IL10, IL1B, and PTGS2/COX-2 gene polymorphisms in relation to risk of colorectal cancer in a prospective Danish case-cohort study.

Authors:  Vibeke Andersen; René Holst; Tine Iskov Kopp; Anne Tjønneland; Ulla Vogel
Journal:  PLoS One       Date:  2013-10-23       Impact factor: 3.240

Review 8.  Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis.

Authors:  Xiao Yang; Pengchao Li; Jun Tao; Chao Qin; Qiang Cao; Jinbao Gu; Xiaheng Deng; Jun Wang; Xuzhong Liu; Zijie Wang; Bian Wu; Min Gu; Qiang Lu; Changjun Yin
Journal:  Int J Genomics       Date:  2014-05-07       Impact factor: 2.326

9.  Increased frequency of Mediterranean fever gene variants in multiple myeloma.

Authors:  Serkan Celik; Fatih Tangi; Cagatay Oktenli
Journal:  Oncol Lett       Date:  2014-08-04       Impact factor: 2.967

10.  Genetic association between NFKB1 -94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies.

Authors:  Duan Wang; Tianhang Xie; Jin Xu; Haoyang Wang; Weinan Zeng; Shuquan Rao; Kai Zhou; Fuxing Pei; Zongke Zhou
Journal:  Sci Rep       Date:  2016-07-22       Impact factor: 4.379
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