OBJECTIVE: To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA). METHODS: We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform activity using spike percentage, the percentage of 1-second bins in the EEG tracing containing at least 1 spike. PSPEA was present when spike percentage during non-REM sleep was ≥50% than spike percentage during wakefulness. RESULTS: One hundred patients with PSPEA (cases) and 47 patients without PSPEA (controls) met the inclusion criteria during a 14-year period. Both groups were comparable in terms of clinical and epidemiologic features. Early developmental lesions were more frequent in cases (48% vs 19.2%, p = 0.002). Thalamic lesions were more frequent in cases (14% vs 2.1%, p = 0.037). The main types of early developmental lesions found in cases were vascular lesions (14%), periventricular leukomalacia (9%), and malformation of cortical development (5%). Vascular lesions were the only type of early developmental lesions that were more frequent in cases (14% vs 0%, p = 0.005). CONCLUSIONS: Patients with PSPEA have a higher frequency of early developmental lesions and thalamic lesions than a comparable population of patients without PSPEA. Vascular lesions were the type of early developmental lesions most related to PSPEA.
OBJECTIVE: To compare the prevalence and type of early developmental lesions in patients with a clinical presentation consistent with electrical status epilepticus in sleep either with or without prominent sleep-potentiated epileptiform activity (PSPEA). METHODS: We performed a case-control study and enrolled patients with 1) clinical features consistent with electrical status epilepticus in sleep, 2) ≥1 brain MRI scan, and 3) ≥1 overnight EEG recording. We quantified epileptiform activity using spike percentage, the percentage of 1-second bins in the EEG tracing containing at least 1 spike. PSPEA was present when spike percentage during non-REM sleep was ≥50% than spike percentage during wakefulness. RESULTS: One hundred patients with PSPEA (cases) and 47 patients without PSPEA (controls) met the inclusion criteria during a 14-year period. Both groups were comparable in terms of clinical and epidemiologic features. Early developmental lesions were more frequent in cases (48% vs 19.2%, p = 0.002). Thalamic lesions were more frequent in cases (14% vs 2.1%, p = 0.037). The main types of early developmental lesions found in cases were vascular lesions (14%), periventricular leukomalacia (9%), and malformation of cortical development (5%). Vascular lesions were the only type of early developmental lesions that were more frequent in cases (14% vs 0%, p = 0.005). CONCLUSIONS:Patients with PSPEA have a higher frequency of early developmental lesions and thalamic lesions than a comparable population of patients without PSPEA. Vascular lesions were the type of early developmental lesions most related to PSPEA.
Authors: C A Tassinari; G Rubboli; L Volpi; S Meletti; G d'Orsi; M Franca; A R Sabetta; P Riguzzi; E Gardella; A Zaniboni; R Michelucci Journal: Clin Neurophysiol Date: 2000-09 Impact factor: 3.708
Authors: Emily L Thorn; Lauren M Ostrowski; Dhinakaran M Chinappen; Jin Jing; M Brandon Westover; Steven M Stufflebeam; Mark A Kramer; Catherine J Chu Journal: Epilepsia Date: 2020-09-18 Impact factor: 5.864
Authors: Iván Sánchez Fernández; Kevin E Chapman; Jurriaan M Peters; Sanjeev V Kothare; Douglas R Nordli; Frances E Jensen; Anne T Berg; Tobias Loddenkemper Journal: Epilepsia Date: 2012-11-16 Impact factor: 5.864
Authors: Mark A Kramer; Sally M Stoyell; Dhinakaran Chinappen; Lauren M Ostrowski; Elizabeth R Spencer; Amy K Morgan; Britt Carlson Emerton; Jin Jing; M Brandon Westover; Uri T Eden; Robert Stickgold; Dara S Manoach; Catherine J Chu Journal: J Neurosci Date: 2021-01-19 Impact factor: 6.167
Authors: Iván Sánchez Fernández; Kevin E Chapman; Jurriaan M Peters; Chellamani Harini; Alexander Rotenberg; Tobias Loddenkemper Journal: Epilepsy Res Treat Date: 2013-08-06
Authors: Bart van den Munckhof; Anne F Zwart; Lauren C Weeke; Nathalie H P Claessens; Joost D J Plate; Alexander Leemans; Hugo J Kuijf; Heleen C van Teeseling; Frans S S Leijten; Manon J N Benders; Kees P J Braun; Linda S de Vries; Floor E Jansen Journal: Neuroimage Clin Date: 2020-02-25 Impact factor: 4.881