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Literature DB >> 2253942

Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes.

Abstract

The expression of folate sensitive common fragile sites was investigated in 82 normal healthy males and females of various ages. In 100 studied metaphases of each of these controls, between 0 and 56 lesions were detected (mean 18.3 +/- 10.3 SD). No significant difference was found between the mean number of expressed lesions in females and males. No age-effects were observed. Two "new" common fragile sites were discovered at 6p21 and 17q21. Their fragile site status, however, needs to be confirmed.

Entities: Chemical Species

Mesh：

Substances：
Folic Acid

Year: 1990 PMID： 2253942 DOI： 10.1007/bf00205178

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

16 in total

1. No significant relationship between age and frequency of chromosome lesions in mentally retarded individuals with or without the fragile X syndrome.

Authors: M G Butler
Journal: Hum Genet Date: 1990-01 Impact factor: 4.132

2. A guide to fragile sites on human chromosomes.

Authors: F Hecht; K H Ramesh; D H Lockwood
Journal: Cancer Genet Cytogenet Date: 1990-01

3. Chromosomes of older humans are more prone to aminopterine-induced breakage.

Authors: D Esposito; G Fassina; P Szabo; P De Angelis; L Rodgers; M Weksler; M Siniscalco
Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

4. The frequency of chromosome aberrations in a control population.

Authors: E J Tawn
Journal: Mutat Res Date: 1987-12 Impact factor: 2.433

5. Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of age range.

Authors: M A Bender; R J Preston; R C Leonard; B E Pyatt; P C Gooch
Journal: Mutat Res Date: 1989-06 Impact factor: 2.433

6. Fragile sites induced by FUdR, caffeine, and aphidicolin. Their frequency, distribution, and analysis.

Authors: P N Rao; N A Heerema; C G Palmer
Journal: Hum Genet Date: 1988-01 Impact factor: 4.132

7. Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers.

Authors: C S Kao-Shan; R L Fine; J Whang-Peng; E C Lee; B A Chabner
Journal: Cancer Res Date: 1987-12-01 Impact factor: 12.701

Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes.

1. No significant relationship between age and frequency of chromosome lesions in mentally retarded individuals with or without the fragile X syndrome.

2. A guide to fragile sites on human chromosomes.

3. Chromosomes of older humans are more prone to aminopterine-induced breakage.

4. The frequency of chromosome aberrations in a control population.

5. Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of age range.

6. Fragile sites induced by FUdR, caffeine, and aphidicolin. Their frequency, distribution, and analysis.

7. Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers.

8. The most common fragile site in man is 3p14.

9. Familial and individual variation in chromosome fragility.

1. Population cytogenetics of aphidicolin-induced fragile sites.

2. The enigma of common fragile sites.