Literature DB >> 22538719

Cell type-specific eQTLs in the human immune system.

Peter K Gregersen1.   

Abstract

A new study reports the mapping of gene expression in primary immune cell subsets, showing the presence of cell type-specific cis and trans expression quantitative trait loci (eQTLs). The identification of cell type-specific trans-regulated networks can inform functional studies of susceptibility loci identified from genome-wide association studies for human complex diseases.

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Year:  2012        PMID： 22538719     DOI： 10.1038/ng.2258

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

Review 1.  Genomics and the multifactorial nature of human autoimmune disease.

Authors:  Judy H Cho; Peter K Gregersen
Journal:  N Engl J Med       Date:  2011-10-27       Impact factor: 91.245

Review 2.  Regulation of mRNA translation and stability by microRNAs.

Authors:  Marc Robert Fabian; Nahum Sonenberg; Witold Filipowicz
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

3.  Dendritic cell and macrophage heterogeneity in vivo.

Authors:  Daigo Hashimoto; Jennifer Miller; Miriam Merad
Journal:  Immunity       Date:  2011-09-23       Impact factor: 31.745

Review 4.  B cells and immunological tolerance.

Authors:  Nataly Manjarrez-Orduño; Tâm D Quách; Iñaki Sanz
Journal:  J Invest Dermatol       Date:  2009-02       Impact factor: 8.551

5.  Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.

Authors:  Bing Ge; Dmitry K Pokholok; Tony Kwan; Elin Grundberg; Lisanne Morcos; Dominique J Verlaan; Jennie Le; Vonda Koka; Kevin C L Lam; Vincent Gagné; Joana Dias; Rose Hoberman; Alexandre Montpetit; Marie-Michele Joly; Edward J Harvey; Daniel Sinnett; Patrick Beaulieu; Robert Hamon; Alexandru Graziani; Ken Dewar; Eef Harmsen; Jacek Majewski; Harald H H Göring; Anna K Naumova; Mathieu Blanchette; Kevin L Gunderson; Tomi Pastinen
Journal:  Nat Genet       Date:  2009-10-18       Impact factor: 38.330

6.  Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Authors:  Calliope A Dendrou; Vincent Plagnol; Erik Fung; Jennie H M Yang; Kate Downes; Jason D Cooper; Sarah Nutland; Gillian Coleman; Matthew Himsworth; Matthew Hardy; Oliver Burren; Barry Healy; Neil M Walker; Kerstin Koch; Willem H Ouwehand; John R Bradley; Nicholas J Wareham; John A Todd; Linda S Wicker
Journal:  Nat Genet       Date:  2009-08-23       Impact factor: 38.330

Review 7.  Multistep pathogenesis of autoimmune disease.

Authors:  Christopher C Goodnow
Journal:  Cell       Date:  2007-07-13       Impact factor: 41.582

8.  Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

Authors:  Benjamin P Fairfax; Seiko Makino; Jayachandran Radhakrishnan; Katharine Plant; Stephen Leslie; Alexander Dilthey; Peter Ellis; Cordelia Langford; Fredrik O Vannberg; Julian C Knight
Journal:  Nat Genet       Date:  2012-03-25       Impact factor: 38.330

9.  A user's guide to the encyclopedia of DNA elements (ENCODE).

Authors: 
Journal:  PLoS Biol       Date:  2011-04-19       Impact factor: 8.029

10.  Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

Authors:  Rudolf S N Fehrmann; Ritsert C Jansen; Jan H Veldink; Harm-Jan Westra; Danny Arends; Marc Jan Bonder; Jingyuan Fu; Patrick Deelen; Harry J M Groen; Asia Smolonska; Rinse K Weersma; Robert M W Hofstra; Wim A Buurman; Sander Rensen; Marcel G M Wolfs; Mathieu Platteel; Alexandra Zhernakova; Clara C Elbers; Eleanora M Festen; Gosia Trynka; Marten H Hofker; Christiaan G J Saris; Roel A Ophoff; Leonard H van den Berg; David A van Heel; Cisca Wijmenga; Gerard J Te Meerman; Lude Franke
Journal:  PLoS Genet       Date:  2011-08-04       Impact factor: 5.917
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  7 in total

1.  A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing.

Authors:  Irena Roci; Hector Gallart-Ayala; Jeramie Watrous; Mohit Jain; Craig E Wheelock; Roland Nilsson
Journal:  J Vis Exp       Date:  2017-02-04       Impact factor: 1.355

2.  Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells.

Authors:  Irena Roci; Hector Gallart-Ayala; Angelika Schmidt; Jeramie Watrous; Mohit Jain; Craig E Wheelock; Roland Nilsson
Journal:  Anal Chem       Date:  2016-02-17       Impact factor: 6.986

Review 3.  The major histocompatibility complex: a model for understanding graft-versus-host disease.

Authors:  Effie W Petersdorf
Journal:  Blood       Date:  2013-07-22       Impact factor: 22.113

Review 4.  Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives.

Authors:  Laurent Abel; Jacques Fellay; David W Haas; Erwin Schurr; Geetha Srikrishna; Michael Urbanowski; Nimisha Chaturvedi; Sudha Srinivasan; Daniel H Johnson; William R Bishai
Journal:  Lancet Infect Dis       Date:  2017-10-27       Impact factor: 25.071

Review 5.  Human genetics of tuberculosis: a long and winding road.

Authors:  Laurent Abel; Jamila El-Baghdadi; Ahmed Aziz Bousfiha; Jean-Laurent Casanova; Erwin Schurr
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2014-05-12       Impact factor: 6.237

6.  Overlap of expression quantitative trait loci (eQTL) in human brain and blood.

Authors:  Marna McKenzie; Anjali K Henders; Anthony Caracella; Naomi R Wray; Joseph E Powell
Journal:  BMC Med Genomics       Date:  2014-06-03       Impact factor: 3.063

7.  Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.

Authors:  Anand Kumar Andiappan; Rossella Melchiotti; Tuang Yeow Poh; Michelle Nah; Kia Joo Puan; Elena Vigano; Doreen Haase; Nurhashikin Yusof; Boris San Luis; Josephine Lum; Dilip Kumar; Shihui Foo; Li Zhuang; Anusha Vasudev; Astrid Irwanto; Bernett Lee; Alessandra Nardin; Hong Liu; Furen Zhang; John Connolly; Jianjun Liu; Alessandra Mortellaro; De Yun Wang; Michael Poidinger; Anis Larbi; Francesca Zolezzi; Olaf Rotzschke
Journal:  Nat Commun       Date:  2015-08-10       Impact factor: 14.919
  7 in total

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