Literature DB >> 2253835

Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats.

H Rothe1, K Fehsel, H Kolb.   

Abstract

Following activation peritoneal macrophages from diabetes prone BB rats secreted strikingly higher amounts of tumour necrosis factor alpha than found for macrophages from diabetes resistant or normal Wistar rats. Enhanced tumour necrosis factor alpha production was detected prior to the occurrence of insulitis. Cultures of macrophages derived from precursor cells in diabetes prone BB rat bone marrow also showed upregulated tumour necrosis factor alpha secretion upon challenge with endotoxin and interferon gamma. Tumour necrosis factor alpha hypersecretion may contribute to autoimmune diabetes by affecting thymic and post-thymic T-cell maturation and by promoting pancreatic islet inflammation.

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Year:  1990        PMID： 2253835     DOI： 10.1007/bf00404147

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  9 in total

1.  Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

Authors:  B Appels; V Burkart; G Kantwerk-Funke; J Funda; V Kolb-Bachofen; H Kolb
Journal:  J Immunol       Date:  1989-06-01       Impact factor: 5.422

2.  Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans.

Authors:  T Mandrup-Poulsen; K Bendtzen; J Nerup; C A Dinarello; M Svenson; J H Nielsen
Journal:  Diabetologia       Date:  1986-01       Impact factor: 10.122

3.  Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.

Authors:  G Buchan; K Barrett; M Turner; D Chantry; R N Maini; M Feldmann
Journal:  Clin Exp Immunol       Date:  1988-09       Impact factor: 4.330

4.  Association between HLA-DR2 and production of tumour necrosis factor alpha and interleukin 1 by mononuclear cells activated by lipopolysaccharide.

Authors:  K Bendtzen; N Morling; A Fomsgaard; M Svenson; B Jakobsen; N Odum; A Svejgaard
Journal:  Scand J Immunol       Date:  1988-11       Impact factor: 3.487

5.  Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis.

Authors:  C O Jacob; H O McDevitt
Journal:  Nature       Date:  1988-01-28       Impact factor: 49.962

6.  Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1.

Authors:  C Pukel; H Baquerizo; A Rabinovitch
Journal:  Diabetes       Date:  1988-01       Impact factor: 9.461

7.  Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

Authors:  J Satoh; H Seino; T Abo; S Tanaka; S Shintani; S Ohta; K Tamura; T Sawai; T Nobunaga; T Oteki
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

8.  Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats.

Authors:  H Hanenberg; V Kolb-Bachofen; G Kantwerk-Funke; H Kolb
Journal:  Diabetologia       Date:  1989-02       Impact factor: 10.122

9.  Downregulation of tumor necrosis factor (TNF) sensitivity via modulation of TNF binding capacity by protein kinase C activators.

Authors:  R Unglaub; B Maxeiner; B Thoma; K Pfizenmaier; P Scheurich
Journal:  J Exp Med       Date:  1987-12-01       Impact factor: 14.307
  9 in total
  12 in total

Review 1.  The role of interleukin-1 in the pathogenesis of IDDM.

Authors:  T Mandrup-Poulsen
Journal:  Diabetologia       Date:  1996-09       Impact factor: 10.122

2.  Decreased expression of adhesion molecules on monocytes in recent onset IDDM.

Authors:  S Martin; H Rothe; D Tschöpe; B Schwippert; H Kolb
Journal:  Immunology       Date:  1991-05       Impact factor: 7.397

3.  Increasing incidence of IDDM a consequence of improved hygiene?

Authors:  H Kolb; R B Elliott
Journal:  Diabetologia       Date:  1994-07       Impact factor: 10.122

Review 4.  Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes.

Authors:  Ashley R Burg; Hubert M Tse
Journal:  Antioxid Redox Signal       Date:  2017-11-27       Impact factor: 8.401

5.  Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.

Authors:  K Hirasawa; H S Jun; K Maeda; Y Kawaguchi; S Itagaki; T Mikami; H S Baek; K Doi; J W Yoon
Journal:  J Virol       Date:  1997-05       Impact factor: 5.103

6.  High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors.

Authors:  A Tafuri; W E Bowers; E S Handler; M Appel; R Lew; D Greiner; J P Mordes; A A Rossini
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

7.  Abnormal TNF-alpha production in diabetes-prone BB rats: enhanced TNF-alpha expression and defective PGE2 feedback inhibition.

Authors:  H Rothe; C Ongören; S Martin; P Rösen; H Kolb
Journal:  Immunology       Date:  1994-03       Impact factor: 7.397

8.  The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat.

Authors:  G Wu; N E Flynn
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

9.  Circulating monocytes are activated in newly diagnosed type 1 diabetes mellitus patients.

Authors:  K Josefsen; H Nielsen; S Lorentzen; P Damsbo; K Buschard
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330

10.  Oxygen radicals generated by the enzyme xanthine oxidase lyse rat pancreatic islet cells in vitro.

Authors:  V Burkart; T Koike; H H Brenner; H Kolb
Journal:  Diabetologia       Date:  1992-11       Impact factor: 10.122
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