Literature DB >> 22538272

Nothing in medicine makes sense, except in the light of evolution.

Ajit Varki1.   

Abstract

The practice of medicine is a fruitful marriage of classic diagnostic and healing arts with modern advancements in many relevant sciences. The scientific aspects of medicine are rooted in understanding the biology of our species and those of other organisms that interact with us in health and disease. Thus, it is reasonable to paraphrase Dobzhansky, stating that, "nothing in the biological aspects of medicine makes sense except in the light of evolution." However, the art and science of medicine are also rooted in the unusual cognitive abilities of humans and the cultural evolutionary processes arising. This explains the rather bold and inclusive title of this essay. The near complete absence of evolution in medical school curricula is a historical anomaly that needs correction. Otherwise, we will continue to train generations of physicians who lack understanding of some fundamental principles that should guide both medical practice and research. I here recount my attempts to correct this deficiency at my own medical school and the lessons learned. I also attempt to summarize what I teach in the limited amount of time allowed for the purpose. Particular attention is given to the value of comparing human physiology and disease with those of other closely related species. There is a long way to go before the teaching of evolution can be placed in its rightful context within the medical curriculum. However, the trend is in the right direction. Let us aim for a day when an essay like this will no longer be relevant.

Entities:  

Mesh:

Year:  2012        PMID: 22538272     DOI: 10.1007/s00109-012-0900-5

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN: 0946-2716            Impact factor:   4.599


  76 in total

1.  Ecological importance of trichromatic vision to primates.

Authors:  N J Dominy; P W Lucas
Journal:  Nature       Date:  2001-03-15       Impact factor: 49.962

2.  Maladaptation and natural selection.

Authors:  Randolph M Nesse
Journal:  Q Rev Biol       Date:  2005-03       Impact factor: 4.875

Review 3.  Parturition.

Authors:  Roger Smith
Journal:  N Engl J Med       Date:  2007-01-18       Impact factor: 91.245

Review 4.  Energy, evolution, and human diseases: an overview.

Authors:  Jesse Roth; Alessandra L Szulc; Ann Danoff
Journal:  Am J Clin Nutr       Date:  2011-02-02       Impact factor: 7.045

Review 5.  Evolutionary approaches to sexually transmitted infections.

Authors:  Randolph M Nesse; Betsy Foxman
Journal:  Ann N Y Acad Sci       Date:  2011-08       Impact factor: 5.691

Review 6.  Infection, immunoregulation, and cancer.

Authors:  Graham A W Rook; Angus Dalgleish
Journal:  Immunol Rev       Date:  2011-03       Impact factor: 12.988

Review 7.  Evolutionary-developmental perspectives on immune system interactions among the pregnant woman, placenta, and fetus, and responses to sexually transmitted infectious agents.

Authors:  André J Nahmias; Jens Schollin; Carlos Abramowsky
Journal:  Ann N Y Acad Sci       Date:  2011-08       Impact factor: 5.691

8.  Recommendations for probiotic use-2011 update.

Authors:  Martin H Floch; W Allan Walker; Karen Madsen; Mary Ellen Sanders; George T Macfarlane; Harry J Flint; Levinus A Dieleman; Yehuda Ringel; Stefano Guandalini; Ciaran P Kelly; Lawrence J Brandt
Journal:  J Clin Gastroenterol       Date:  2011-11       Impact factor: 3.062

9.  Inference of human population history from individual whole-genome sequences.

Authors:  Heng Li; Richard Durbin
Journal:  Nature       Date:  2011-07-13       Impact factor: 49.962

10.  Heart disease is common in humans and chimpanzees, but is caused by different pathological processes.

Authors:  Nissi Varki; Dan Anderson; James G Herndon; Tho Pham; Christopher J Gregg; Monica Cheriyan; James Murphy; Elizabeth Strobert; Jo Fritz; James G Else; Ajit Varki
Journal:  Evol Appl       Date:  2009-02       Impact factor: 5.183

View more
  8 in total

1.  The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine.

Authors:  Detlev Ganten; Randolph Nesse
Journal:  J Mol Med (Berl)       Date:  2012-05       Impact factor: 4.599

Review 2.  Evolutionary medicine: its scope, interest and potential.

Authors:  Stephen C Stearns
Journal:  Proc Biol Sci       Date:  2012-08-29       Impact factor: 5.349

Review 3.  On the apparent rarity of epithelial cancers in captive chimpanzees.

Authors:  Nissi M Varki; Ajit Varki
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-07-19       Impact factor: 6.237

Review 4.  Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease.

Authors:  Zhe Lyu; William B Whitman
Journal:  Cell Mol Life Sci       Date:  2016-06-03       Impact factor: 9.261

5.  The status of evolutionary medicine education in North American medical schools.

Authors:  Brandon H Hidaka; Anila Asghar; C Athena Aktipis; Randolph M Nesse; Terry M Wolpaw; Nicole K Skursky; Katelyn J Bennett; Matthew W Beyrouty; Mark D Schwartz
Journal:  BMC Med Educ       Date:  2015-03-08       Impact factor: 2.463

Review 6.  Disease consequences of human adaptation.

Authors:  Justin C Fay
Journal:  Appl Transl Genom       Date:  2013-08-22

7.  Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome.

Authors:  Supaporn Thamadilok; Kyoung-Soo Choi; Lorenz Ruhl; Fabian Schulte; A Latif Kazim; Markus Hardt; Omer Gokcumen; Stefan Ruhl
Journal:  Mol Biol Evol       Date:  2020-02-01       Impact factor: 16.240

8.  Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length.

Authors:  Mirna Marinić; Katelyn Mika; Sravanthi Chigurupati; Vincent J Lynch
Journal:  Elife       Date:  2021-02-01       Impact factor: 8.140

  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.