| Literature DB >> 22537642 |
Juan Zou1, Jing Jiang, Yan-Yan Diao, Li-Bin Yang, Jin Huang, Hong-Lin Li, Xue Du, Wei-Lie Xiao, Jian-Xin Pu, Han-Dong Sun.
Abstract
Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC(50) of 1.50 μM.Entities:
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Year: 2012 PMID： 22537642 DOI： 10.1016/j.fitote.2012.04.007
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882