OBJECTIVE: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC). METHODS: CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction. RESULTS: Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival. CONCLUSIONS: Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.
OBJECTIVE: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC). METHODS:CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCCpatients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction. RESULTS: Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival. CONCLUSIONS: Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCCpatients undergoing resection.
Authors: Ae Lee Jeong; Sunyi Lee; Jeong Su Park; Sora Han; Chang-Young Jang; Jong-Seok Lim; Myung Sok Lee; Young Yang Journal: J Biol Chem Date: 2013-11-08 Impact factor: 5.157