Literature DB >> 22537143

Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes.

Liangguang Wang1, Xiaoqiang Yu, Xiujuan Feng, Ming Bao.   

Abstract

An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 22537143     DOI: 10.1021/ol300872e

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Crystal structure and Hirshfeld surface analysis of (Z)-4-(4-hy-droxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one.

Authors:  Wissem Zemamouche; Rima Laroun; Noudjoud Hamdouni; Ouarda Brihi; Ali Boudjada; Abdelmadjid Debache
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-06-08
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.