Literature DB >> 2253704

Characterization of 5-HT3 receptors in intact N1E-115 neuroblastoma cells.

S C Lummis1, G J Kilpatrick, I L Martin.   

Abstract

The highly selective 5-HT3 receptor antagonist [3H]GR65630 has been used to characterize 5-HT3 receptors in intact N1E-115 neuroblastoma cells. Equilibrium binding analysis demonstrated high-affinity binding to a single class of receptors with a Kd of 0.69 (+/- 0.12) nM and Bmax of 31.4 (+/- 11.4) fmol/10(5) cells, equivalent to approximately 200,000 sites per cell. Specific binding was displaced by low concentrations of 5-HT3-selective ligands, and by the nicotinic antagonist d-tubocurarine.

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Year:  1990        PMID： 2253704     DOI： 10.1016/0922-4106(90)90026-t

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

Review 1.  The 5-HT3 receptor as a therapeutic target.

Authors:  Andrew J Thompson; Sarah C R Lummis
Journal:  Expert Opin Ther Targets       Date:  2007-04       Impact factor: 6.902

2.  Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells.

Authors:  M Barann; K Ruppert; M Göthert; H Bönisch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

3.  Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium.

Authors:  H Bönisch; M Barann; J Graupner; M Göthert
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

Review 4.  5-HT3 receptors.

Authors:  A J Thompson; S C R Lummis
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

5.  Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists.

Authors:  J A van Hooft; H P Vijverberg
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

6.  The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells.

Authors:  M I Sepúlveda; S C Lummis; I L Martin
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

7.  Competitive and non-competitive effects of 5-hydroxyindole on 5-HT3 receptors in N1E-115 neuroblastoma cells.

Authors:  A R Kooyman; J A van Hooft; P M Vanderheijden; H P Vijverberg
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739

8.  Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity.

Authors:  P M Sweetnam; J Lancaster; A Snowman; J L Collins; S Perschke; C Bauer; J Ferkany
Journal:  Psychopharmacology (Berl)       Date:  1995-04       Impact factor: 4.530

Review 9.  Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).

Authors:  H Bönisch; K B Fink; B Malinowska; G J Molderings; E Schlicker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2021-05-15       Impact factor: 3.000
  9 in total

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