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Literature DB >> 2253672

Dose dependent enzyme induction by oxcarbazepine?

P N Patsalos¹, J M Zakrzewska, A A Elyas.

Abstract

Antipyrine half life and clearance was compared in four patients with classical idiopathic trigeminal neuralgia during carbamazepine (CBZ) or CBZ/phenytoin (PHT) and after substitution with oxcarbazepine (OXC) monotherapy. OXC is observed to be less of a hepatic enzyme inducer than CBZ or CBZ/PHT in combination, however induction by OXC may be dose related.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2253672 DOI： 10.1007/bf00280057

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

5 in total

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Authors: J M Zakrzewska; P N Patsalos
Journal: J Neurol Neurosurg Psychiatry Date: 1989-04 Impact factor: 10.154

3. Oxcarbazepine (GP 47.680): a possible alternative to carbamazepine?

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Authors: P N Patsalos; J S Duncan; S D Shorvon
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Authors: M Dam; R Ekberg; Y Løyning; O Waltimo; K Jakobsen
Journal: Epilepsy Res Date: 1989 Jan-Feb Impact factor: 3.045

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Authors: S M Grant; D Faulds
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