INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure.
INTRODUCTION: In Brazil there is a large area of overlap of visceral leishmaniasis (VL) and HIV infection, which favored a increased incidence of coinfection Leishmania/HIV. METHODS: This study evaluated 65 consecutive patients with VL and their clinical response to treatment in two health care settings in Belo Horizonte, Brazil. RESULTS: At baseline, the clinical picture was similar between both groups, although diarrhea and peripheral lymphadenomegaly were more frequent in HIV-infected subjects. HIV-positive patients had lower median blood lymphocyte counts (686/mm³ versus 948/mm³p = 0.004) and lower values of alanine aminotransferase (ALT) (48IU/L versus 75.6IU/L p = 0.016) than HIV-negative patients. HIV-positive status (hazard ratio = 0.423, p = 0.023) and anemia (HR = 0.205, p = 0.002) were independent negative predictors of complete clinical response following antileishmanial treatment initiation. CONCLUSIONS: This study reinforces that all patients with VL should be tested for HIV infection, regardless of their clinical picture. This practice would allow early recognition of coinfection with initiation of antiretroviral therapy and, possibly, reduction in treatment failure.
Authors: Daniel Holanda Barroso; Claúdia Elise Ferraz Silva; Ana Carolina Depes Perdigao e Vasconcelos; Silvana Maria de Morais Cavalcanti; Maria Edileuza Felinto de Brito; Angela Cristina Rapela Medeiros Journal: An Bras Dermatol Date: 2015 May-Jun Impact factor: 1.896
Authors: José Angelo Lindoso; Gláucia Fernandes Cota; Alda Maria da Cruz; Hiro Goto; Ana Nilce Silveira Maia-Elkhoury; Gustavo Adolfo Sierra Romero; Márcia Leite de Sousa-Gomes; Joanna Reis Santos-Oliveira; Ana Rabello Journal: PLoS Negl Trop Dis Date: 2014-09-18
Authors: Uiara Regina Silva de Lima; Luciano Vanolli; Elizabeth Coelho Moraes; Jorim Severino Ithamar; Conceição de Maria Pedrozo E Silva de Azevedo Journal: PLoS One Date: 2019-12-05 Impact factor: 3.240
Authors: Gláucia F Cota; Marcos R de Sousa; Andrea Laender Pessoa de Mendonça; Allan Patrocinio; Luiza Siqueira Assunção; Sidnei Rodrigues de Faria; Ana Rabello Journal: PLoS Negl Trop Dis Date: 2014-04-17