Literature DB >> 22534641

The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans.

Li Yang1, Yunfeng Ding, Yong Chen, Shuyan Zhang, Chaoxing Huo, Yang Wang, Jinhai Yu, Peng Zhang, Huimin Na, Huina Zhang, Yanbin Ma, Pingsheng Liu.   

Abstract

Lipid droplets are cellular organelles that consists of a neutral lipid core covered by a monolayer of phospholipids and many proteins. They are thought to function in the storage, transport, and metabolism of lipids, in signaling, and as a specialized microenvironment for metabolism in most types of cells from prokaryotic to eukaryotic organisms. Lipid droplets have received a lot of attention in the last 10 years as they are linked to the progression of many metabolic diseases and hold great potential for the development of neutral lipid-derived products, such as biofuels, food supplements, hormones, and medicines. Proteomic analysis of lipid droplets has yielded a comprehensive catalog of lipid droplet proteins, shedding light on the function of this organelle and providing evidence that its function is conserved from bacteria to man. This review summarizes many of the proteomic studies on lipid droplets from a wide range of organisms, providing an evolutionary perspective on this organelle.

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Year:  2012        PMID： 22534641      PMCID： PMC3371236          DOI： 10.1194/jlr.R024117

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  104 in total

Review 1.  The biogenesis and functions of lipid bodies in animals, plants and microorganisms.

Authors:  D J Murphy
Journal:  Prog Lipid Res       Date:  2001-09       Impact factor: 16.195

2.  Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.

Authors:  Christine Moessinger; Lars Kuerschner; Johanna Spandl; Andrej Shevchenko; Christoph Thiele
Journal:  J Biol Chem       Date:  2011-04-15       Impact factor: 5.157

3.  Lipid bodies in coral-dinoflagellate endosymbiosis: proteomic and ultrastructural studies.

Authors:  Shao-En Peng; Wan-Nan U Chen; Hung-Kai Chen; Chi-Yu Lu; Anderson B Mayfield; Lee-Shing Fang; Chii-Shiarng Chen
Journal:  Proteomics       Date:  2011-07-27       Impact factor: 3.984

4.  Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLsd1).

Authors:  Atsushi Ohnishi; J Joe Hull; Misato Kaji; Kana Hashimoto; Jae Min Lee; Kazuhide Tsuneizumi; Takehiro Suzuki; Naoshi Dohmae; Shogo Matsumoto
Journal:  J Biol Chem       Date:  2011-05-15       Impact factor: 5.157

5.  Interactomic study on interaction between lipid droplets and mitochondria.

Authors:  Jing Pu; Cheol Woong Ha; Shuyan Zhang; Jong Pil Jung; Won-Ki Huh; Pingsheng Liu
Journal:  Protein Cell       Date:  2011-07-12       Impact factor: 14.870

Review 6.  The contribution of the Drosophila model to lipid droplet research.

Authors:  Ronald P Kühnlein
Journal:  Prog Lipid Res       Date:  2011-05-17       Impact factor: 16.195

7.  Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.

Authors:  K Reue; P Xu; X P Wang; B G Slavin
Journal:  J Lipid Res       Date:  2000-07       Impact factor: 5.922

8.  Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells.

Authors:  C C Wu; K E Howell; M C Neville; J R Yates; J L McManaman
Journal:  Electrophoresis       Date:  2000-10       Impact factor: 3.535

9.  The adipophilin C terminus is a self-folding membrane-binding domain that is important for milk lipid secretion.

Authors:  Brandi M Chong; Tanya D Russell; Jerome Schaack; David J Orlicky; Philip Reigan; Mark Ladinsky; James L McManaman
Journal:  J Biol Chem       Date:  2011-03-07       Impact factor: 5.157

10.  TIP47 associates with lipid droplets.

Authors:  N E Wolins; B Rubin; D L Brasaemle
Journal:  J Biol Chem       Date:  2000-11-17       Impact factor: 5.157
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  82 in total

Review 1.  Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.

Authors:  Sathish Kumar Natarajan; Karuna Rasineni; Murali Ganesan; Dan Feng; Benita L McVicker; Mark A McNiven; Natalia A Osna; Justin L Mott; Carol A Casey; Kusum K Kharbanda
Journal:  Curr Mol Pharmacol       Date:  2017       Impact factor: 3.339

2.  Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease.

Authors:  Wen Su; Yang Wang; Xiao Jia; Wenhan Wu; Linghai Li; Xiaodong Tian; Sha Li; Chunjiong Wang; Huamin Xu; Jiaqi Cao; Qifei Han; Shimeng Xu; Yong Chen; Yanfeng Zhong; Xiaoyan Zhang; Pingsheng Liu; Jan-Åke Gustafsson; Youfei Guan
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-15       Impact factor: 11.205

3.  The evolutionary conserved oil body associated protein OBAP1 participates in the regulation of oil body size.

Authors:  Ignacio López-Ribera; José Luis La Paz; Carlos Repiso; Nora García; Mercè Miquel; María Luisa Hernández; José Manuel Martínez-Rivas; Carlos M Vicient
Journal:  Plant Physiol       Date:  2014-01-09       Impact factor: 8.340

Review 4.  Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.

Authors:  Theresa D'Aquila; Yu-Han Hung; Alicia Carreiro; Kimberly K Buhman
Journal:  Biochim Biophys Acta       Date:  2016-04-20

Review 5.  As the fat flies: The dynamic lipid droplets of Drosophila embryos.

Authors:  Michael A Welte
Journal:  Biochim Biophys Acta       Date:  2015-04-13

Review 6.  The assembly of lipid droplets and their roles in challenged cells.

Authors:  W Mike Henne; Michael L Reese; Joel M Goodman
Journal:  EMBO J       Date:  2018-05-22       Impact factor: 11.598

7.  Isolating lipid droplets from multiple species.

Authors:  Yunfeng Ding; Shuyan Zhang; Li Yang; Huimin Na; Peng Zhang; Huina Zhang; Yang Wang; Yong Chen; Jinhai Yu; Chaoxing Huo; Shimeng Xu; Martina Garaiova; Yusheng Cong; Pingsheng Liu
Journal:  Nat Protoc       Date:  2012-12-06       Impact factor: 13.491

8.  Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets.

Authors:  Jennifer L Groebner; Marlene T Girón-Bravo; Mia L Rothberg; Raghabendra Adhikari; Dean J Tuma; Pamela L Tuma
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-08-02       Impact factor: 4.052

9.  PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia.

Authors:  Ibrahim Bildirici; W Timothy Schaiff; Baosheng Chen; Mayumi Morizane; Soo-Young Oh; Matthew O'Brien; Christina Sonnenberg-Hirche; Tianjiao Chu; Yaacov Barak; D Michael Nelson; Yoel Sadovsky
Journal:  Endocrinology       Date:  2018-12-01       Impact factor: 4.736

10.  The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Authors:  Daniel Ferguson; Jun Zhang; Matthew A Davis; Robert N Helsley; Lise-Lotte Vedin; Richard G Lee; Rosanne M Crooke; Mark J Graham; Daniela S Allende; Paolo Parini; J Mark Brown
Journal:  J Lipid Res       Date:  2016-12-10       Impact factor: 5.922
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