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Literature DB >> 22533439

Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease.

Marta Balietti¹, Francesco Tamagnini, Patrizia Fattoretti, Costanza Burattini, Tiziana Casoli, Daniela Platano, Fabrizia Lattanzio, Giorgio Aicardi.

Abstract

Aging is associated with a gradual decline in cognitive functions, and more dramatic cognitive impairments occur in patients affected by Alzheimer's disease (AD). Electrophysiological and molecular studies performed in aged animals and in animal models of AD have shown that cognitive decline is associated with significant modifications in synaptic plasticity (i.e., activity-dependent changes in synaptic strength) and have elucidated some of the cellular mechanisms underlying this process. Morphological studies have revealed a correlation between the quality of memory performance and the extent of structural changes of synaptic contacts occurring during memory consolidation. We briefly review recent experimental evidence here.

Entities: Disease Species

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Year: 2012 PMID： 22533439 PMCID： PMC3332390 DOI： 10.1089/rej.2012.1318

Source DB: PubMed Journal: Rejuvenation Res ISSN： 1549-1684 Impact factor: 4.663

29 in total

1. Calcineurin links Ca2+ dysregulation with brain aging.

Authors: T C Foster; K M Sharrow; J R Masse; C M Norris; A Kumar
Journal: J Neurosci Date: 2001-06-01 Impact factor: 6.167

2. Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease.

Authors: Francesco Tamagnini; Costanza Burattini; Tiziana Casoli; Marta Balietti; Patrizia Fattoretti; Giorgio Aicardi
Journal: Rejuvenation Res Date: 2012-04 Impact factor: 4.663

Review 3. Synaptic and mitochondrial physiopathologic changes in the aging nervous system and the role of zinc ion homeostasis.

Authors: Carlo Bertoni-Freddari; Eugenio Mocchegiani; Marco Malavolta; Tiziana Casoli; Giuseppina Di Stefano; Patrizia Fattoretti
Journal: Mech Ageing Dev Date: 2006-03-07 Impact factor: 5.432

4. Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats.

Authors: Marta Balietti; Patrizia Fattoretti; Belinda Giorgetti; Tiziana Casoli; Giuseppina Di Stefano; Daniela Platano; Giorgio Aicardi; Fabrizia Lattanzio; Carlo Bertoni-Freddari
Journal: Microsc Res Tech Date: 2009-12 Impact factor: 2.769

5. A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats.

Authors: Marta Balietti; Belinda Giorgetti; Giuseppina Di Stefano; Tiziana Casoli; Daniela Platano; Moreno Solazzi; Carlo Bertoni-Freddari; Giorgio Aicardi; Fabrizia Lattanzio; Patrizia Fattoretti
Journal: Micron Date: 2009-10-08 Impact factor: 2.251

6. Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.

Authors: Thelma R Cowley; Joan O'Sullivan; Christoph Blau; Brian F Deighan; Raasay Jones; Christian Kerskens; Jill C Richardson; David Virley; Neil Upton; Marina A Lynch
Journal: Neurobiol Aging Date: 2010-04-10 Impact factor: 4.673

7. Dynamin binding protein gene expression and memory performance in aged rats.

Authors: Tiziana Casoli; Giuseppina Di Stefano; Patrizia Fattoretti; Belinda Giorgetti; Marta Balietti; Fabrizia Lattanzio; Giorgio Aicardi; Daniela Platano
Journal: Neurobiol Aging Date: 2011-01-12 Impact factor: 4.673

Review 8. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Authors: Robert W Mahley; Karl H Weisgraber; Yadong Huang
Journal: Proc Natl Acad Sci U S A Date: 2006-03-27 Impact factor: 11.205

Review 9. The expanding role of BDNF: a therapeutic target for Alzheimer's disease?

Authors: F Fumagalli; G Racagni; M A Riva
Journal: Pharmacogenomics J Date: 2006 Jan-Feb Impact factor: 3.550

10. Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity.

Authors: Yan Zeng; Danyun Zhao; Cui-Wei Xie
Journal: J Alzheimers Dis Date: 2010 Impact factor: 4.472

9 in total

1. Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.

Authors: Anne Wiemhoefer; Anita Stargardt; Wouter A van der Linden; Maria C Renner; Ronald E van Kesteren; Jan Stap; Marcel A Raspe; Birgitta Tomkinson; Helmut W Kessels; Huib Ovaa; Herman S Overkleeft; Bogdan Florea; Eric A Reits
Journal: Mol Cell Proteomics Date: 2015-06-03 Impact factor: 5.911

Review 2. Brain response to calorie restriction.

Authors: Salvatore Fusco; Giovambattista Pani
Journal: Cell Mol Life Sci Date: 2012-12-27 Impact factor: 9.261

Review 3. Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes.

Authors: Ke Hao; Antonio Fabio Di Narzo; Lap Ho; Wei Luo; Shuyu Li; Rong Chen; Tongbin Li; Lauren Dubner; Giulio Maria Pasinetti
Journal: Mol Aspects Med Date: 2015-06-23

4. Life-time expression of the proteins peroxiredoxin, beta-synuclein, PARK7/DJ-1, and stathmin in the primary visual and primary somatosensory cortices in rats.

Authors: Michael R R Böhm; Harutyun Melkonyan; Solon Thanos
Journal: Front Neuroanat Date: 2015-03-04 Impact factor: 3.856

5. Differential Roles of Environmental Enrichment in Alzheimer's Type of Neurodegeneration and Physiological Aging.

Authors: Vladimir V Salmin; Yulia K Komleva; Natalia V Kuvacheva; Andrey V Morgun; Elena D Khilazheva; Olga L Lopatina; Elena A Pozhilenkova; Konstantin A Shapovalov; Yulia A Uspenskaya; Alla B Salmina
Journal: Front Aging Neurosci Date: 2017-07-26 Impact factor: 5.750