BACKGROUND: While the liver is a frequent site of metastatic spread for malignant cutaneous as well as malignant ocular melanoma, isolated hepatic metastases without evidence of systemic disease is rare. Hepatic resection has been proposed as a therapeutic and potentially curative procedure in metastatic melanoma patients with isolated hepatic metastases. OBJECTIVE: To report two metastatic melanoma patients with isolated hepatic metastases treated with partial hepatectomy. In addition, the literature is reviewed and the management and efficacy of surgical excision for isolated hepatic disease in the setting of malignant melanoma is discussed. CASE REPORT: A 34-year-old woman with metastatic cutaneous melanoma and a 55-year-old man with metastatic ocular melanoma are presented. Both patients developed isolated hepatic metastases detected during routine surveillance following resection of their primary disease and underwent partial hepatectomy. CONCLUSION: In select cases, partial hepatectomy is an efficacious and potentially curative treatment for metastatic melanoma patients with isolated hepatic metastases.
BACKGROUND: While the liver is a frequent site of metastatic spread for malignant cutaneous as well as malignant ocular melanoma, isolated hepatic metastases without evidence of systemic disease is rare. Hepatic resection has been proposed as a therapeutic and potentially curative procedure in metastatic melanomapatients with isolated hepatic metastases. OBJECTIVE: To report two metastatic melanomapatients with isolated hepatic metastases treated with partial hepatectomy. In addition, the literature is reviewed and the management and efficacy of surgical excision for isolated hepatic disease in the setting of malignant melanoma is discussed. CASE REPORT: A 34-year-old woman with metastatic cutaneous melanoma and a 55-year-old man with metastatic ocular melanoma are presented. Both patients developed isolated hepatic metastases detected during routine surveillance following resection of their primary disease and underwent partial hepatectomy. CONCLUSION: In select cases, partial hepatectomy is an efficacious and potentially curative treatment for metastatic melanomapatients with isolated hepatic metastases.
Authors: U Pastorino; M Buyse; G Friedel; R J Ginsberg; P Girard; P Goldstraw; M Johnston; P McCormack; H Pass; J B Putnam Journal: J Thorac Cardiovasc Surg Date: 1997-01 Impact factor: 5.209
Authors: S Leyvraz; V Spataro; J Bauer; S Pampallona; R Salmon; T Dorval; R Meuli; M Gillet; F Lejeune; L Zografos Journal: J Clin Oncol Date: 1997-07 Impact factor: 44.544
Authors: T F Wood; L A DiFronzo; D M Rose; P I Haigh; S L Stern; L Wanek; R Essner; D L Morton Journal: Ann Surg Oncol Date: 2001-09 Impact factor: 5.344
Authors: Alexander L Vahrmeijer; Cornelis J H van de Velde; Henk H Hartgrink; Rob A E M Tollenaar Journal: Dig Surg Date: 2009-02-12 Impact factor: 2.588
Authors: Marie Diener-West; Sandra M Reynolds; Donna J Agugliaro; Robert Caldwell; Kristi Cumming; John D Earle; Donna L Green; Barbara S Hawkins; James Hayman; Ishmael Jaiyesimi; John M Kirkwood; Wui-Jin Koh; Dennis M Robertson; John M Shaw; Jonni Thoma Journal: J Clin Oncol Date: 2004-06-15 Impact factor: 44.544
Authors: S Peters; V Voelter; L Zografos; S Pampallona; R Popescu; M Gillet; W Bosshard; G Fiorentini; M Lotem; R Weitzen; U Keilholz; Y Humblet; S Piperno-Neumann; R Stupp; S Leyvraz Journal: Ann Oncol Date: 2006-02-09 Impact factor: 32.976
Authors: A Y Bedikian; S S Legha; G Mavligit; C H Carrasco; S Khorana; C Plager; N Papadopoulos; R S Benjamin Journal: Cancer Date: 1995-11-01 Impact factor: 6.860
Authors: Marybeth S Hughes; Jonathan Zager; Mark Faries; H Richard Alexander; Richard E Royal; Bradford Wood; Junsung Choi; Kevin McCluskey; Eric Whitman; Sanjiv Agarwala; Gary Siskin; Charles Nutting; Mary Ann Toomey; Carole Webb; Tatiana Beresnev; James F Pingpank Journal: Ann Surg Oncol Date: 2015-11-23 Impact factor: 5.344