Literature DB >> 22532001

Amphiphilic α-helix mimetics based on a benzoylurea scaffold.

Sam Thompson1, Andrew D Hamilton.   

Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

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Year:  2012        PMID： 22532001     DOI： 10.1039/c2ob25273b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  13 in total

1.  Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.

Authors:  Misook Oh; Ji Hoon Lee; Wei Wang; Hui Sun Lee; Woo Sirl Lee; Christopher Burlak; Wonpil Im; Quyen Q Hoang; Hyun-Suk Lim
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-14       Impact factor: 11.205

2.  Synthesis of a tetrasubstituted tetrahydronaphthalene scaffold for α-helix mimicry via a MgBr2-catalyzed Friedel-Crafts epoxide cycloalkylation.

Authors:  Devan Naduthambi; Santosh Bhor; Michael B Elbaum; Neal J Zondlo
Journal:  Org Lett       Date:  2013-09-09       Impact factor: 6.005

3.  Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue.

Authors:  Laura Nevola; Johanna M Rodriguez; Sam Thompson; Andrew D Hamilton
Journal:  Supramol Chem       Date:  2013-09-01       Impact factor: 1.688

4.  Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.

Authors:  M E Lanning; P T Wilder; H Bailey; B Drennen; M Cavalier; L Chen; J L Yap; M Raje; S Fletcher
Journal:  Org Biomol Chem       Date:  2015-07-24       Impact factor: 3.876

Review 5.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Authors:  Marta Pelay-Gimeno; Adrian Glas; Oliver Koch; Tom N Grossmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-26       Impact factor: 15.336

6.  Orthogonal functionalisation of α-helix mimetics.

Authors:  Anna Barnard; Kérya Long; David J Yeo; Jennifer A Miles; Valeria Azzarito; George M Burslem; Panchami Prabhakaran; Thomas A Edwards; Andrew J Wilson
Journal:  Org Biomol Chem       Date:  2014-09-21       Impact factor: 3.876

7.  Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Authors:  Gesa Schäfer; Jelena Milić; Adeeb Eldahshan; Frank Götz; Kerstin Zühlke; Christian Schillinger; Annika Kreuchwig; Jonathan M Elkins; Kamal R Abdul Azeez; Andreas Oder; Marie C Moutty; Nanako Masada; Monika Beerbaum; Brigitte Schlegel; Sylvia Niquet; Peter Schmieder; Gerd Krause; Jens Peter von Kries; Dermot M F Cooper; Stefan Knapp; Jörg Rademann; Walter Rosenthal; Enno Klussmann
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-23       Impact factor: 15.336

8.  β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.

Authors:  Chanwoo Kim; Jinjoo Jung; Truong T Tung; Seung Bum Park
Journal:  Chem Sci       Date:  2015-12-15       Impact factor: 9.825

Review 9.  Multi-Facial, Non-Peptidic α-Helix Mimetics.

Authors:  Maryanna E Lanning; Steven Fletcher
Journal:  Biology (Basel)       Date:  2015-08-31

10.  Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.

Authors:  Brooke Bullock Lao; Kevin Drew; Danielle A Guarracino; Thomas F Brewer; Daniel W Heindel; Richard Bonneau; Paramjit S Arora
Journal:  J Am Chem Soc       Date:  2014-05-23       Impact factor: 15.419
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