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Literature DB >> 22531936

Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat.

Tengfei Zhao¹, Yan Li, Xuesong Dai, Junbo Wang, Yiying Qi, Jianwei Wang, Kan Xu.

Abstract

Recovery after spinal cord injury (SCI) is rare in humans and experimental animals. Following SCI in adults, changes in gene expression and the regulation of these genes are associated with the pathological development of the injury. High levels of brain-derived neurotrophic factor (BDNF) in the injury area during the post-injury period contribute to enhanced neuroprotection and axonal regeneration. Intervention at the level of gene regulation has the potential to promote SCI repair. In this study, the injection of adenovirus-mediated BDNF in the lesion area (rostral spinal cord) up-regulated the expression of BDNF in the injury zone of a compression model in rat, thereby protecting neurons and enhancing behavioral function.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22531936 DOI： 10.1007/s11033-012-1651-7

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

31 in total

Review 1. Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord.

Authors: William T Hendriks; Marc J Ruitenberg; Bas Blits; Gerard J Boer; Joost Verhaagen
Journal: Prog Brain Res Date: 2004 Impact factor: 2.453

2. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer.

Authors: Armin Blesch
Journal: Methods Date: 2004-06 Impact factor: 3.608

3. Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector.

Authors: Hideaki Nakajima; Kenzo Uchida; Shigeru Kobayashi; Yasuo Kokubo; Takafumi Yayama; Ryuichiro Sato; Hisatoshi Baba
Journal: Neurosci Lett Date: 2005-09-02 Impact factor: 3.046

4. Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration.

Authors: L N Novikova; L N Novikov; J O Kellerth
Journal: Eur J Neurosci Date: 2000-02 Impact factor: 3.386

5. Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression.

Authors: Kan Xu; Kenzo Uchida; Hideaki Nakajima; Shigeru Kobayashi; Hisatoshi Baba
Journal: Spine (Phila Pa 1976) Date: 2006-08-01 Impact factor: 3.468

6. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death.

Authors: Simone Di Giovanni; Susan M Knoblach; Cinzia Brandoli; Sadia A Aden; Eric P Hoffman; Alan I Faden
Journal: Ann Neurol Date: 2003-04 Impact factor: 10.422

Review 7. Combination strategies for repair, plasticity, and regeneration using regulation of gene expression during the chronic phase after spinal cord injury.

Authors: Christine G Gerin; Ikenna C Madueke; Tina Perkins; Seritta Hill; Kristin Smith; Benjamin Haley; Shannon A Allen; Richard P Garcia; Tanjana Paunesku; Gayle Woloschak
Journal: Synapse Date: 2011-12 Impact factor: 2.562

Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat.

Review 1. Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord.

2. Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer.

3. Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector.

4. Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration.

5. Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression.

6. Gene profiling in spinal cord injury shows role of cell cycle in neuronal death.

Review 7. Combination strategies for repair, plasticity, and regeneration using regulation of gene expression during the chronic phase after spinal cord injury.

8. Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury.

Review 9. Degenerative and regenerative mechanisms governing spinal cord injury.

10. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.

1. Regulatory effect of neuroglobin in the recovery of spinal cord injury.

2. Correlation between TSC1 gene polymorphism and epilepsy.

Review 3. Recombinant Adenoviruses for Delivery of Therapeutics Following Spinal Cord Injury.

4. Anatomic connections of the diaphragm: influence of respiration on the body system.