Literature DB >> 22531759

High diagnostic yield of tuberculosis from screening urine samples from HIV-infected patients with advanced immunodeficiency using the Xpert MTB/RIF assay.

Stephen D Lawn1, Andrew D Kerkhoff, Monica Vogt, Robin Wood.   

Abstract

We determined the diagnostic yield of the Xpert MTB/RIF assay for tuberculosis (TB) when testing small volumes of urine from ambulatory HIV-infected patients before starting antiretroviral therapy in South Africa. Compared with a gold standard of sputum culture, the sensitivity of urine Xpert among those with CD4 cell counts of <50, 50-100, and >100 cells per microliter were 44.4%, 25.0%, and 2.7% (P = 0.001), respectively. Urine Xpert testing provides a means of rapid TB diagnosis in patients with advanced immunodeficiency and poor prognosis. These data are indicative of high rates of TB dissemination and renal involvement in this clinical population.

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Year:  2012        PMID： 22531759      PMCID： PMC3384719          DOI： 10.1097/QAI.0b013e318258c6af

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  26 in total

Review 1.  Xpert® MTB/RIF assay: development, evaluation and implementation of a new rapid molecular diagnostic for tuberculosis and rifampicin resistance.

Authors:  Stephen D Lawn; Mark P Nicol
Journal:  Future Microbiol       Date:  2011-09       Impact factor: 3.165

Review 2.  Novel and improved technologies for tuberculosis diagnosis: progress and challenges.

Authors:  Madhukar Pai; Jessica Minion; Hojoon Sohn; Alice Zwerling; Mark D Perkins
Journal:  Clin Chest Med       Date:  2009-12       Impact factor: 2.878

3.  Diagnosis of extrapulmonary tuberculosis using the Xpert(®) MTB/RIF assay.

Authors:  Stephen D Lawn; Alimuddin I Zumla
Journal:  Expert Rev Anti Infect Ther       Date:  2012-06       Impact factor: 5.091

4.  Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa.

Authors:  Ingrid V Bassett; Bingxia Wang; Senica Chetty; Janet Giddy; Elena Losina; Matilda Mazibuko; Benjamin Bearnot; Jenny Allen; Rochelle P Walensky; Kenneth A Freedberg
Journal:  Clin Infect Dis       Date:  2010-10-01       Impact factor: 9.079

5.  Rapid molecular detection of tuberculosis and rifampin resistance.

Authors:  Catharina C Boehme; Pamela Nabeta; Doris Hillemann; Mark P Nicol; Shubhada Shenai; Fiorella Krapp; Jenny Allen; Rasim Tahirli; Robert Blakemore; Roxana Rustomjee; Ana Milovic; Martin Jones; Sean M O'Brien; David H Persing; Sabine Ruesch-Gerdes; Eduardo Gotuzzo; Camilla Rodrigues; David Alland; Mark D Perkins
Journal:  N Engl J Med       Date:  2010-09-01       Impact factor: 91.245

6.  Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control.

Authors:  Stephen D Lawn; Landon Myer; Linda-Gail Bekker; Robin Wood
Journal:  AIDS       Date:  2006-08-01       Impact factor: 4.177

7.  Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV.

Authors:  R Dawson; P Masuka; D J Edwards; E D Bateman; L-G Bekker; R Wood; S D Lawn
Journal:  Int J Tuberc Lung Dis       Date:  2010-01       Impact factor: 2.373

8.  Extrapulmonary tuberculosis in patients with human immunodeficiency virus infection.

Authors:  R W Shafer; D S Kim; J P Weiss; J M Quale
Journal:  Medicine (Baltimore)       Date:  1991-11       Impact factor: 1.889

9.  Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease.

Authors:  Stephen D Lawn; David J Edwards; Katharina Kranzer; Monica Vogt; Linda-Gail Bekker; Robin Wood
Journal:  AIDS       Date:  2009-09-10       Impact factor: 4.177

Review 10.  Tuberculosis in antiretroviral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis.

Authors:  Stephen D Lawn; Robin Wood
Journal:  J Infect Dis       Date:  2011-11-15       Impact factor: 5.226
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  30 in total

1.  Xpert MTB/RIF Results in Patients With Previous Tuberculosis: Can We Distinguish True From False Positive Results?

Authors:  Grant Theron; Rouxjeane Venter; Greg Calligaro; Liezel Smith; Jason Limberis; Richard Meldau; Duncan Chanda; Aliasgar Esmail; Jonny Peter; Keertan Dheda
Journal:  Clin Infect Dis       Date:  2016-02-16       Impact factor: 9.079

2.  Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults.

Authors:  Lydia Nakiyingi; Vineshree Mischka Moodley; Yukari C Manabe; Mark P Nicol; Molly Holshouser; Derek T Armstrong; Widaad Zemanay; Welile Sikhondze; Olive Mbabazi; Bareng A S Nonyane; Maunank Shah; Moses L Joloba; David Alland; Jerrold J Ellner; Susan E Dorman
Journal:  J Acquir Immune Defic Syndr       Date:  2014-07-01       Impact factor: 3.731

3.  The role of technical assistance in expanding access to Xpert(®) MTB/RIF: experience in sub-Saharan Africa.

Authors:  A N Umubyeyi; F Bonsu; R Chimzizi; S Jemal; M Melese; E Ruttoh; C Mundy
Journal:  Public Health Action       Date:  2016-02-12

Review 4.  Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.

Authors:  Karen R Steingart; Ian Schiller; David J Horne; Madhukar Pai; Catharina C Boehme; Nandini Dendukuri
Journal:  Cochrane Database Syst Rev       Date:  2014-01-21

Review 5.  Diagnostic accuracy of nucleic acid amplification tests in urine for pulmonary tuberculosis: a meta-analysis.

Authors:  D Marangu; B Devine; G John-Stewart
Journal:  Int J Tuberc Lung Dis       Date:  2015-11       Impact factor: 2.373

6.  Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults.

Authors:  Mikashmi Kohli; Ian Schiller; Nandini Dendukuri; Mandy Yao; Keertan Dheda; Claudia M Denkinger; Samuel G Schumacher; Karen R Steingart
Journal:  Cochrane Database Syst Rev       Date:  2021-01-15

7.  Accuracy and incremental yield of urine Xpert MTB/RIF Ultra versus Determine TB-LAM for diagnosis of pulmonary tuberculosis.

Authors:  A Andama; D Jaganath; R Crowder; L Asege; M Nakaye; D Katumba; S Mwebe; F Semitala; W Worodria; M Joloba; S Mohanty; A Somoskovi; A Cattamanchi
Journal:  Diagn Microbiol Infect Dis       Date:  2019-09-04       Impact factor: 2.803

8.  Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa.

Authors:  R K Gupta; S D Lawn; L-G Bekker; J Caldwell; R Kaplan; R Wood
Journal:  Int J Tuberc Lung Dis       Date:  2013-08       Impact factor: 2.373

Review 9.  Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance.

Authors:  Mikashmi Kohli; Ian Schiller; Nandini Dendukuri; Keertan Dheda; Claudia M Denkinger; Samuel G Schumacher; Karen R Steingart
Journal:  Cochrane Database Syst Rev       Date:  2018-08-27

Review 10.  Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test.

Authors:  Stephen D Lawn; Peter Mwaba; Matthew Bates; Amy Piatek; Heather Alexander; Ben J Marais; Luis E Cuevas; Timothy D McHugh; Lynn Zijenah; Nathan Kapata; Ibrahim Abubakar; Ruth McNerney; Michael Hoelscher; Ziad A Memish; Giovanni Battista Migliori; Peter Kim; Markus Maeurer; Marco Schito; Alimuddin Zumla
Journal:  Lancet Infect Dis       Date:  2013-03-24       Impact factor: 25.071
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