| Literature DB >> 22531313 |
Martha W den Hollander1, Jourik A Gietema, Steven de Jong, Annemiek M E Walenkamp, Anna K L Reyners, Corina N A M Oldenhuis, Elisabeth G E de Vries.
Abstract
The extrinsic apoptotic pathway can be activated by the endogenous ligand TRAIL (Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand) by binding to the death receptors TRAIL-R1 and TRAIL-R2 on the cell surface. This pathway is currently evaluated as an anticancer treatment strategy. Both recombinant human TRAIL and several agonistic antibodies against TRAIL-R1 and R2 have been studied in single agent and combination studies and proved to be safe and well tolerated. In this article, the clinical studies published to date will be reviewed. Also, future perspectives and biomarker studies for selecting patients that will benefit from these agents will be discussed.Entities:
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Year: 2012 PMID： 22531313 DOI： 10.1016/j.canlet.2012.04.007
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679