Literature DB >> 22529873

SIGIRR, a negative regulator of colon tumorigenesis.

Junjie Zhao1, Jarod Zepp, Katarzyna Bulek, Xiaoxia Li.   

Abstract

Inappropriate activation of the Toll-IL-1R (TL-IL-1) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified SIGIRR as a negative regulator of TL-IL-1 signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.

Entities:  

Year:  2012        PMID： 22529873      PMCID： PMC3331713          DOI： 10.1016/j.ddmec.2012.02.003

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  46 in total

1.  Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.

Authors:  Hui Xiao; Weiguo Yin; Mohammed A Khan; Muhammet F Gulen; Hang Zhou; Ho Pan Sham; Kevan Jacobson; Bruce A Vallance; Xiaoxia Li
Journal:  Gastroenterology       Date:  2010-04-21       Impact factor: 22.682

2.  The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells.

Authors:  Mohammed A Khan; Theodore S Steiner; Ho Pan Sham; Kirk S Bergstrom; Jingtian T Huang; Kiran Assi; Bill Salh; Isabella T Tai; Xiaoxia Li; Bruce A Vallance
Journal:  J Immunol       Date:  2010-02-03       Impact factor: 5.422

3.  IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

Authors:  Sergei Grivennikov; Eliad Karin; Janos Terzic; Daniel Mucida; Guann-Yi Yu; Sivakumar Vallabhapurapu; Jürgen Scheller; Stefan Rose-John; Hilde Cheroutre; Lars Eckmann; Michael Karin
Journal:  Cancer Cell       Date:  2009-02-03       Impact factor: 31.743

4.  The expression pattern of TIR8 is conserved among vertebrates.

Authors:  Federica Riva; Nadia Polentarutti; Giulia Tribbioli; Alberto Mantovani; Cecilia Garlanda; Lauretta Turin
Journal:  Vet Immunol Immunopathol       Date:  2009-03-24       Impact factor: 2.046

5.  Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors.

Authors:  Masayuki Fukata; Yasmin Hernandez; Daisy Conduah; Jason Cohen; Anli Chen; Keith Breglio; Tyralee Goo; David Hsu; Ruliang Xu; Maria T Abreu
Journal:  Inflamm Bowel Dis       Date:  2009-07       Impact factor: 5.325

6.  The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts.

Authors:  Marina Noris; Paola Cassis; Nadia Azzollini; Regiane Cavinato; Daniela Cugini; Federica Casiraghi; Sistiana Aiello; Samantha Solini; Linda Cassis; Marilena Mister; Marta Todeschini; Mauro Abbate; Ariela Benigni; Piera Trionfini; Susanna Tomasoni; Caterina Mele; Cecilia Garlanda; Nadia Polentarutti; Alberto Mantovani; Giuseppe Remuzzi
Journal:  J Immunol       Date:  2009-09-04       Impact factor: 5.422

7.  The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

Authors:  Muhammet F Gulen; Zizhen Kang; Katarzyna Bulek; Wan Youzhong; Tae Whan Kim; Yi Chen; Cengiz Z Altuntas; Kristian Sass Bak-Jensen; Mandy J McGeachy; Jeong-Su Do; Hui Xiao; Greg M Delgoffe; Booki Min; Jonathan D Powell; Vincent K Tuohy; Daniel J Cua; Xiaoxia Li
Journal:  Immunity       Date:  2010-01-07       Impact factor: 31.745

8.  Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family.

Authors:  Cecilia Garlanda; Federica Riva; Tania Veliz; Nadia Polentarutti; Fabio Pasqualini; Enrico Radaelli; Marina Sironi; Manuela Nebuloni; Elisabetta Omodeo Zorini; Eugenio Scanziani; Alberto Mantovani
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

Review 9.  Toll-like receptors.

Authors:  Kiyoshi Takeda; Tsuneyasu Kaisho; Shizuo Akira
Journal:  Annu Rev Immunol       Date:  2001-12-19       Impact factor: 28.527

10.  Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice.

Authors:  Koji Aoki; Yoshitaka Tamai; Shigeo Horiike; Masanobu Oshima; Makoto M Taketo
Journal:  Nat Genet       Date:  2003-11-16       Impact factor: 38.330
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  5 in total

1.  IL-1R8 Downregulation and Concomitant TLR7 and TLR9 Upregulation Are Related to the Pathogenesis of Canine Diffuse Large B-Cell Lymphoma.

Authors:  Federica Riva; Joel Filipe; Antonella Fanelli; Laura Marconato; Alessia Inglesi; Eugenio Scanziani; Sabina Soldati; Luca Licenziato; Stefano Comazzi; Lucia Minoli; Luca Aresu
Journal:  Vet Sci       Date:  2022-04-25

2.  The decreased frequency of SIGIRR-positive CD4+ T cells in peripheral blood of patients with SLE and its correlation with disease activity.

Authors:  Dao-Yang Wang; Chao Su; Gui-Mei Chen; Hai-Feng Pan; Feng-Mei Wang; Gui-Ling Liu; Li Hao; De-Guang Wang; Dong-Qing Ye
Journal:  Mol Biol Rep       Date:  2014-10-07       Impact factor: 2.316

3.  Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Authors:  Junjie Zhao; Katarzyna Bulek; Muhammet F Gulen; Jarod A Zepp; Georgio Karagkounis; Bradley N Martin; Hao Zhou; Minjia Yu; Xiuli Liu; Emina Huang; Paul L Fox; Matthew F Kalady; Sanford D Markowitz; Xiaoxia Li
Journal:  Gastroenterology       Date:  2015-09-05       Impact factor: 22.682

4.  Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study.

Authors:  Rulin Zhao; Conghua Song; Li Liu; Qiong Liu; Nanjin Zhou; Xiaojiang Zhou; Yong Xie
Journal:  Mol Med Rep       Date:  2020-07-28       Impact factor: 2.952

5.  Dominant-Negative Form of SIGIRR: SIGIRRΔE8 Promotes Tumor Growth Through Regulation of Metabolic Pathways.

Authors:  Malgorzata Bodaszewska-Lubas; Yun Liao; Aneta Zegar; Oskar Szelest; Jurek Dobrucki; Katarzyna Bulek
Journal:  J Interferon Cytokine Res       Date:  2022-07-27       Impact factor: 3.657
  5 in total

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