Sir,Head and neck infections normally arise from Streptococcus, Staphylococcus, or other anaerobic species, and infection by Salmonella is rare.[1] According to a recent review, there have been about 10 cases of neck abscesses with soft tissue involvement by various non-typhoidal Salmonella (NTS) serovars, reported worldwide in the last 10 years.[2] Salmonella paratyphi A, one of the causative agents of enteric fever, has rarely been implicated in focal suppurative complications.[3-6] This report presents the first ever case of neck abscess caused by Salmonella paratyphi A, a typhoidal Salmonella serovar, without classical presentations of enteric fever, in a young male without any known predisposing factors.A 22-year-old male was referred with a complaint of painful swelling involving entire right neck for seven days. On admission, the patient was febrile with a body temperature of 37.6°C. On physical examination, there was gross cellulitis involving the right neck, with tenderness, local rise of temperature, and the overlying skin appeared slightly erythematous. Laboratory findings revealed white cell count of 13.2×109/L with 86% neutrophils, 6.0% lymphocytes; hemoglobin 14.8 g/dL, hematocrit 44%, platelet count 1.81×109/L. On ultrasonography of neck, there was gross cellulitis with soft tissue edema; abscess was seen confined to the neck measuring 30 mm × 40 mm with associated cervical lymphadenopathy. Under local anesthesia, incision and drainage of the abscess was performed and the patient was empirically started on intravenous amoxicillin–clavulanic acid. Gram stain of the purulent material revealed plenty of polymorphonuclear cells, and no microorganisms, later on culture, pure growth of smooth, translucent; non-lactose fermenting colonies were obtained on MacConkey agar. The isolate was identified as Salmonella paratyphi A by conventional biochemical reactions and by MicroScan Walk-Away 40® (Dade Behring Inc., West Sacramento, CA). The Salmonella isolate was sent for serotyping to National Salmonella reference centre, Kasauli, Himachal Pradesh, India, and was identified as Salmonella paratyphi A (2, 12: a:-). The isolate was sensitive to amikacin, ampicillin, ampicillin/sulbactam, amoxicillin–clavulanic acid, ceftriaxone, cefuroxime, chloramphenicol, ciprofloxacin, levofloxacin, moxifloxacin, trimethoprim/sulfamethoxazole and tobramycin. Blood cultures obtained at days 1 and 3 of admission were found to be sterile. Patient was discharged home in a stable condition. Amoxicillin–clavulanic acid, to which the isolate was susceptible, was continued for total period of three weeks. After initial clinical improvement for one month, the patient was again admitted with similar complaints. Incision and drainage was done and culture of the aspirate revealed pure growth of Salmonella paratyphi A with identical antimicrobial susceptibility. Repeat blood and urine cultures were found to be sterile. Stool culture did not reveal the presence of Salmonella paratyphi. Widal test was negative. Patient was found to be HIV sero-negative. Patient was advised oral moxifloxacin 400 mg for 4 weeks. Clinical examination reported satisfactory outcome at three months and six months of follow-up, with no recurrence of infection.The conventional treatment modality for a Salmonella neck abscess involves incision and drainage, and treatment with the appropriate antibiotics for a minimum of three weeks.[2] In the present case, there was recurrence of infection, despite the Salmonella paratyphi A isolate being susceptible to amoxicillin–clavulanic acid. The long-term administration of oral quinolone was considered necessary to prevent future recurrence.