OBJECTIVE: The aim of this study was to evaluate the microstructure of various regions of the brain using diffusion-tensor imaging (DTI) in patients with sickle cell disease (SCD) and in age- and sex-matched healthy control subjects. We also investigated the fiber tractography findings of the corpus callosum (CC) and corticospinal tracts (CSTs). SUBJECTS AND METHODS: Sixteen right-handed patients with SCD and 14 age- and sex-matched right-handed healthy control subjects were scanned using conventional MR sequences and DTI. Fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) were calculated and regions of interest were selected in various brain areas (superior and inferior frontal, parietal, occipital, and temporal white matter areas), anterior and posterior periventricular areas, centrum semiovale, basal ganglia (lentiform nucleus, head of caudate nucleus), thalamus, cerebral peduncles, pons, cerebellar white matter areas, and CC. Diffusion-tensor tractography of the CC and CSTs was also performed. RESULTS: For the patients with SCD, significantly reduced FA values, increased ADC values, or both were seen clustered in several brain areas, including the CC, frontal white matter, centrum semiovale, periventricular areas, head of the caudate nucleus, thalamus, brainstem, and pons (p < 0.05). Statistically significant reductions in fiber counts in the first and fifth segments of the CC and in CSTs bilaterally were also observed in patients with SCD (p < 0.05). CONCLUSION: DTI shows microstructural abnormalities of various brain areas in patients with SCD.
OBJECTIVE: The aim of this study was to evaluate the microstructure of various regions of the brain using diffusion-tensor imaging (DTI) in patients with sickle cell disease (SCD) and in age- and sex-matched healthy control subjects. We also investigated the fiber tractography findings of the corpus callosum (CC) and corticospinal tracts (CSTs). SUBJECTS AND METHODS: Sixteen right-handed patients with SCD and 14 age- and sex-matched right-handed healthy control subjects were scanned using conventional MR sequences and DTI. Fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) were calculated and regions of interest were selected in various brain areas (superior and inferior frontal, parietal, occipital, and temporal white matter areas), anterior and posterior periventricular areas, centrum semiovale, basal ganglia (lentiform nucleus, head of caudate nucleus), thalamus, cerebral peduncles, pons, cerebellar white matter areas, and CC. Diffusion-tensor tractography of the CC and CSTs was also performed. RESULTS: For the patients with SCD, significantly reduced FA values, increased ADC values, or both were seen clustered in several brain areas, including the CC, frontal white matter, centrum semiovale, periventricular areas, head of the caudate nucleus, thalamus, brainstem, and pons (p < 0.05). Statistically significant reductions in fiber counts in the first and fifth segments of the CC and in CSTs bilaterally were also observed in patients with SCD (p < 0.05). CONCLUSION: DTI shows microstructural abnormalities of various brain areas in patients with SCD.
Authors: Yaqiong Chai; Adam M Bush; Julie Coloigner; Aart J Nederveen; Benita Tamrazi; Chau Vu; Soyoung Choi; Thomas D Coates; Natasha Lepore; John C Wood Journal: Am J Hematol Date: 2019-02-21 Impact factor: 10.047
Authors: Soyoung Choi; Sharon H O'Neil; Anand A Joshi; Jian Li; Adam M Bush; Thomas D Coates; Richard M Leahy; John C Wood Journal: Am J Hematol Date: 2019-07-23 Impact factor: 10.047
Authors: Julie Coloigner; Yeun Kim; Adam Bush; Matt Borzage; Vidya Rajagopalan; Natasha Lepore; John Wood Journal: Proc SPIE Int Soc Opt Eng Date: 2015-12-22
Authors: Andria L Ford; Dustin K Ragan; Slim Fellah; Michael M Binkley; Melanie E Fields; Kristin P Guilliams; Hongyu An; Lori C Jordan; Robert C McKinstry; Jin-Moo Lee; Michael R DeBaun Journal: Blood Date: 2018-07-30 Impact factor: 25.476