OBJECTIVE: The objective of our study was to investigate the feasibility and reproducibility of blood oxygenation level-dependent (BOLD) MRI using different gradient echoes at 3 T in patients with renal allografts and healthy volunteers and to evaluate whether BOLD MRI can be used to distinguish between cases of acute allograft rejection and normally functioning allografts. SUBJECTS AND METHODS: BOLD MRI at 3 T was performed of eight patients with normal allografts, four patients with acute allograft rejection, and 10 healthy volunteers. Multiple fast-field echo sequences were performed at gradient echoes of 8, 16, and 20 to obtain T2(*)-weighted images. The reproducibility of BOLD MRI was evaluated in patients with normal allografts. RESULTS: Cortical and medullary R2(*) values were not significantly different between healthy volunteers and patients with normal allografts, but medullary R2(*) values were significantly greater than cortical R2(*) values in both groups for all three protocols (p < 0.01). Medullary R2(*) values were significantly lower in cases of acute allograft rejection than in normal allografts for all three protocols (p < 0.001). The mean difference in cortical or medullary R2(*) values was 3.8% or less in all protocols. CONCLUSION: BOLD MRI performed using different gradient echoes at 3 T is feasible and reproducible in patients with renal allografts and can show significant changes in medullary oxygenation in patients with acute rejection.
OBJECTIVE: The objective of our study was to investigate the feasibility and reproducibility of blood oxygenation level-dependent (BOLD) MRI using different gradient echoes at 3 T in patients with renal allografts and healthy volunteers and to evaluate whether BOLD MRI can be used to distinguish between cases of acute allograft rejection and normally functioning allografts. SUBJECTS AND METHODS: BOLD MRI at 3 T was performed of eight patients with normal allografts, four patients with acute allograft rejection, and 10 healthy volunteers. Multiple fast-field echo sequences were performed at gradient echoes of 8, 16, and 20 to obtain T2(*)-weighted images. The reproducibility of BOLD MRI was evaluated in patients with normal allografts. RESULTS: Cortical and medullary R2(*) values were not significantly different between healthy volunteers and patients with normal allografts, but medullary R2(*) values were significantly greater than cortical R2(*) values in both groups for all three protocols (p < 0.01). Medullary R2(*) values were significantly lower in cases of acute allograft rejection than in normal allografts for all three protocols (p < 0.001). The mean difference in cortical or medullary R2(*) values was 3.8% or less in all protocols. CONCLUSION: BOLD MRI performed using different gradient echoes at 3 T is feasible and reproducible in patients with renal allografts and can show significant changes in medullary oxygenation in patients with acute rejection.
Authors: Eleanor F Cox; Charlotte E Buchanan; Christopher R Bradley; Benjamin Prestwich; Huda Mahmoud; Maarten Taal; Nicholas M Selby; Susan T Francis Journal: Front Physiol Date: 2017-09-14 Impact factor: 4.566
Authors: David J Niles; Nathan S Artz; Arjang Djamali; Elizabeth A Sadowski; Thomas M Grist; Sean B Fain Journal: Invest Radiol Date: 2016-02 Impact factor: 6.016
Authors: Mick J M van Eijs; Arjan D van Zuilen; Anneloes de Boer; Martijn Froeling; Tri Q Nguyen; Jaap A Joles; Tim Leiner; Marianne C Verhaar Journal: Front Physiol Date: 2017-05-16 Impact factor: 4.566
Authors: Oriane Hanssen; Pauline Erpicum; Pierre Lovinfosse; Paul Meunier; Laurent Weekers; Luaba Tshibanda; Jean-Marie Krzesinski; Roland Hustinx; François Jouret Journal: Clin Kidney J Date: 2016-07-28