Literature DB >> 22528786

Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system.

Patricia Y W Dankers1, Thomas M Hermans, Travis W Baughman, Yuko Kamikawa, Roxanne E Kieltyka, Maartje M C Bastings, Henk M Janssen, Nico A J M Sommerdijk, Antje Larsen, Marja J A van Luyn, Anton W Bosman, Eliane R Popa, George Fytas, E W Meijer.   

Abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22528786     DOI： 10.1002/adma.201104072

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  35 in total

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