Literature DB >> 22528520

The complex genetic basis of plasma triglycerides.

Christopher T Johansen1, Robert A Hegele.   

Abstract

Demonstration of a direct relationship between plasma triglyceride (TG) concentration and atherosclerosis has proven difficult due to confounding variables that accompany elevated plasma TG, such as other dyslipidemias, obesity, and type 2 diabetes. However, human genetic studies have provided evidence suggesting a causal link between plasma TG and cardiovascular risk. Analyses in human patients with hypertriglyceridemia (HTG) also provides insight into the relationship between genetic variation, predisposition to elevated plasma TG, and risk of subsequent cardiovascular disease. Here, we review recent key studies that have contributed to our understanding of the genetic determinants of plasma TG concentration, including HTG susceptibility and phenotypic heterogeneity, and discuss our maturing model of the allelic and phenotypic spectrum of plasma TG.

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Year:  2012        PMID： 22528520     DOI： 10.1007/s11883-012-0243-2

Source DB:  PubMed          Journal:  Curr Atheroscler Rep        ISSN： 1523-3804            Impact factor:   5.113


  36 in total

1.  Apolipoprotein A5 and hypertriglyceridemia.

Authors:  Valentine Charlton-Menys; Paul N Durrington
Journal:  Clin Chem       Date:  2005-02       Impact factor: 8.327

2.  Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment.

Authors:  Christophe Marçais; Bruno Verges; Sybil Charrière; Valérie Pruneta; Micheline Merlin; Stéphane Billon; Laurence Perrot; Jocelyne Drai; Agnès Sassolas; Len A Pennacchio; Jamila Fruchart-Najib; Jean-Charles Fruchart; Vincent Durlach; Philippe Moulin
Journal:  J Clin Invest       Date:  2005-10       Impact factor: 14.808

3.  A specific apoprotein activator for lipoprotein lipase.

Authors:  J C LaRosa; R I Levy; P Herbert; S E Lux; D S Fredrickson
Journal:  Biochem Biophys Res Commun       Date:  1970-10-09       Impact factor: 3.575

4.  Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.

Authors:  Christopher T Johansen; Jian Wang; Matthew B Lanktree; Henian Cao; Adam D McIntyre; Matthew R Ban; Rebecca A Martins; Brooke A Kennedy; Reina G Hassell; Maartje E Visser; Stephen M Schwartz; Benjamin F Voight; Roberto Elosua; Veikko Salomaa; Christopher J O'Donnell; Geesje M Dallinga-Thie; Sonia S Anand; Salim Yusuf; Murray W Huff; Sekar Kathiresan; Robert A Hegele
Journal:  Nat Genet       Date:  2010-07-25       Impact factor: 38.330

5.  Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

Authors:  Stefano Romeo; Len A Pennacchio; Yunxin Fu; Eric Boerwinkle; Anne Tybjaerg-Hansen; Helen H Hobbs; Jonathan C Cohen
Journal:  Nat Genet       Date:  2007-02-25       Impact factor: 38.330

6.  Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression.

Authors:  T G Kirchgessner; R C LeBoeuf; C A Langner; S Zollman; C H Chang; B A Taylor; M C Schotz; J I Gordon; A J Lusis
Journal:  J Biol Chem       Date:  1989-01-25       Impact factor: 5.157

Review 7.  Triglycerides and heart disease: still a hypothesis?

Authors:  Ira J Goldberg; Robert H Eckel; Ruth McPherson
Journal:  Arterioscler Thromb Vasc Biol       Date:  2011-04-28       Impact factor: 8.311

8.  Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects.

Authors:  Remco Franssen; Stephen G Young; Frank Peelman; Jozef Hertecant; Jeroen A Sierts; Alinda W M Schimmel; André Bensadoun; John J P Kastelein; Loren G Fong; Geesje M Dallinga-Thie; Anne P Beigneux
Journal:  Circ Cardiovasc Genet       Date:  2010-02-02

9.  Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

Authors:  Stefano Romeo; Wu Yin; Julia Kozlitina; Len A Pennacchio; Eric Boerwinkle; Helen H Hobbs; Jonathan C Cohen
Journal:  J Clin Invest       Date:  2008-12-15       Impact factor: 14.808

Review 10.  Hypertriglyceridemia: its etiology, effects and treatment.

Authors:  George Yuan; Khalid Z Al-Shali; Robert A Hegele
Journal:  CMAJ       Date:  2007-04-10       Impact factor: 8.262
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  10 in total

Review 1.  Postprandial hypertriglyceridemia and cardiovascular disease: current and future therapies.

Authors:  D C Chan; J Pang; G Romic; G F Watts
Journal:  Curr Atheroscler Rep       Date:  2013-03       Impact factor: 5.113

2.  Increased Binding of Apolipoproteins A-I and E4 to Triglyceride-Rich Lipoproteins is linked to Induction of Hypertriglyceridemia.

Authors:  Irina N Gorshkova; David Atkinson
Journal:  JSM Atheroscler       Date:  2017-02-13

Review 3.  Chylomicronaemia--current diagnosis and future therapies.

Authors:  Amanda J Brahm; Robert A Hegele
Journal:  Nat Rev Endocrinol       Date:  2015-03-03       Impact factor: 43.330

Review 4.  Demystifying the management of hypertriglyceridaemia.

Authors:  Gerald F Watts; Esther M M Ooi; Dick C Chan
Journal:  Nat Rev Cardiol       Date:  2013-09-24       Impact factor: 32.419

5.  Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia.

Authors:  Irina N Gorshkova; Xiaohu Mei; David Atkinson
Journal:  J Lipid Res       Date:  2014-06-11       Impact factor: 5.922

6.  Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia.

Authors:  Elena Mendoza-Barberá; Josep Julve; Stefan K Nilsson; Aivar Lookene; Jesús M Martín-Campos; Rosa Roig; Alfonso M Lechuga-Sancho; John H Sloan; Pablo Fuentes-Prior; Francisco Blanco-Vaca
Journal:  J Lipid Res       Date:  2013-01-10       Impact factor: 5.922

7.  Hypertriglyceridemia.

Authors:  Amanda Brahm; Robert A Hegele
Journal:  Nutrients       Date:  2013-03-22       Impact factor: 5.717

8.  Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks.

Authors:  Zaheda H Radwan; Xingbin Wang; Fahad Waqar; Dilek Pirim; Vipavee Niemsiri; John E Hokanson; Richard F Hamman; Clareann H Bunker; M Michael Barmada; F Yesim Demirci; M Ilyas Kamboh
Journal:  PLoS One       Date:  2014-12-12       Impact factor: 3.240

Review 9.  Genetics of Triglycerides and the Risk of Atherosclerosis.

Authors:  Jacqueline S Dron; Robert A Hegele
Journal:  Curr Atheroscler Rep       Date:  2017-07       Impact factor: 5.113

10.  Apolipoprotein E-C1-C4-C2 gene cluster region and inter-individual variation in plasma lipoprotein levels: a comprehensive genetic association study in two ethnic groups.

Authors:  Dilek Pirim; Zaheda H Radwan; Xingbin Wang; Vipavee Niemsiri; John E Hokanson; Richard F Hamman; Eleanor Feingold; Clareann H Bunker; F Yesim Demirci; M Ilyas Kamboh
Journal:  PLoS One       Date:  2019-03-26       Impact factor: 3.240
  10 in total

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