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Literature DB >> 22528467

Transgenesis applied to goat: current applications and ongoing research.

Laurent Boulanger¹, Bruno Passet, Eric Pailhoux, Jean-Luc Vilotte.

Abstract

Compared to experiments involving pigs, cows and/or sheep, transgenesis applied to goats is probably less advertised. However, recent successes and increasing amount of dedicated research make this species of special interest for ongoing biological and physiological questions on genome engineering in large animals. This short review aims at highlighting the current applications and limitations of the goat genome manipulation.

Entities: Species

Mesh：

Year: 2012 PMID： 22528467 DOI： 10.1007/s11248-012-9618-y

Source DB: PubMed Journal: Transgenic Res ISSN： 0962-8819 Impact factor: 2.788

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References

79 in total

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Authors: Xiao-E Zhao; Bao-Hua Ma; Hao Wu; Yue-Mao Zheng; Yong Zhang
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Transgenesis applied to goat: current applications and ongoing research.

1. Acceptable changes in quality attributes of glycosylated biopharmaceuticals.

2. Targeted genome modification in mice using zinc-finger nucleases.

3. Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors.

4. Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer.

5. Pluripotent male germline stem cells from goat fetal testis and their survival in mouse testis.

6. Production of dairy goat embryos, by nuclear transfer, transgenic for human acid beta-glucosidase.

7. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases.

8. [Production of cloned goats by transfer of nuclei from transfected caprine mammary gland epithelial cells].

9. Hot topic: using a stearoyl-CoA desaturase transgene to alter milk fatty acid composition.

10. [Somatic nuclear transplantation and serial nuclear transplantation of human finger-domain lacking t-PA gene in goat].