Literature DB >> 22528113

Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders.

Allal Boutajangout1, Yong Sheng Li, David Quartermain, Einar M Sigurdsson.   

Abstract

In the last couple of decades, substantial progress has been made in the development of transgenic mouse models developing amyloid-β deposits and/or neurofibrillary tangles. These mouse models of Alzheimer's disease and related disorders provide an excellent tool for investigating etiology, pathogenic mechanisms, and potential treatments. An essential component of their characterization is a detailed behavioral assessment, which clarifies the functional consequences of these pathologies. We have selected and refined a series of cognitive and sensorimotor tasks that are ideal for studying these models and the efficacy of various treatments.

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Year:  2012        PMID： 22528113      PMCID： PMC3859369          DOI： 10.1007/978-1-61779-551-0_35

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  17 in total

1.  Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

Authors:  R J Carter; L A Lione; T Humby; L Mangiarini; A Mahal; G P Bates; S B Dunnett; A J Morton
Journal:  J Neurosci       Date:  1999-04-15       Impact factor: 6.167

2.  Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.

Authors:  J Lewis; E McGowan; J Rockwood; H Melrose; P Nacharaju; M Van Slegtenhorst; K Gwinn-Hardy; M Paul Murphy; M Baker; X Yu; K Duff; J Hardy; A Corral; W L Lin; S H Yen; D W Dickson; P Davies; M Hutton
Journal:  Nat Genet       Date:  2000-08       Impact factor: 38.330

3.  A closed-field intelligence test for rats.

Authors:  M S RABINOVITCH; H E ROSVOLD
Journal:  Can J Psychol       Date:  1951-09

4.  A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice.

Authors:  E Giménez; L Montoliu
Journal:  Lab Anim       Date:  2001-04       Impact factor: 2.471

5.  Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain.

Authors:  Allal Boutajangout; Johanna Ingadottir; Peter Davies; Einar M Sigurdsson
Journal:  J Neurochem       Date:  2011-07-01       Impact factor: 5.372

6.  Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system.

Authors:  E M Torres; T A Perry; A Blockland; L S Wilkinson; R G Wiley; D A Lappi; S B Dunnet
Journal:  Neuroscience       Date:  1994-11       Impact factor: 3.590

7.  Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.

Authors:  Ayodeji A Asuni; Allal Boutajangout; Henrieta Scholtzova; Elin Knudsen; Yong Sheng Li; David Quartermain; Blas Frangione; Thomas Wisniewski; Einar M Sigurdsson
Journal:  Eur J Neurosci       Date:  2006-11       Impact factor: 3.386

8.  Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

Authors:  Ayodeji A Asuni; Allal Boutajangout; David Quartermain; Einar M Sigurdsson
Journal:  J Neurosci       Date:  2007-08-22       Impact factor: 6.167

9.  Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.

Authors:  K Hsiao; P Chapman; S Nilsen; C Eckman; Y Harigaya; S Younkin; F Yang; G Cole
Journal:  Science       Date:  1996-10-04       Impact factor: 47.728

10.  Cretinism in rats: enduring behavioral deficit induced by tricyanoaminopropene.

Authors:  J W Davenport
Journal:  Science       Date:  1970-02-13       Impact factor: 47.728
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  6 in total

1.  Innate Immunity Stimulation via Toll-Like Receptor 9 Ameliorates Vascular Amyloid Pathology in Tg-SwDI Mice with Associated Cognitive Benefits.

Authors:  Henrieta Scholtzova; Eileen Do; Shleshma Dhakal; Yanjie Sun; Shan Liu; Pankaj D Mehta; Thomas Wisniewski
Journal:  J Neurosci       Date:  2017-01-25       Impact factor: 6.167

2.  Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease.

Authors:  Allal Boutajangout; Abdulwahab Noorwali; Hazem Atta; Thomas Wisniewski
Journal:  Curr Alzheimer Res       Date:  2017       Impact factor: 3.498

3.  Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer's Mouse Model With Tau Pathology.

Authors:  Allal Boutajangout; Wei Zhang; Justin Kim; Wed Ali Abdali; Frances Prelli; Thomas Wisniewski
Journal:  Front Aging Neurosci       Date:  2021-02-25       Impact factor: 5.750

4.  TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.

Authors:  Stephanie H Greco; Lena Tomkötter; Anne-Kristin Vahle; Rae Rokosh; Antonina Avanzi; Syed Kashif Mahmood; Michael Deutsch; Sara Alothman; Dalia Alqunaibit; Atsuo Ochi; Constantinos Zambirinis; Tasnima Mohaimin; Mauricio Rendon; Elliot Levie; Mridul Pansari; Alejandro Torres-Hernandez; Donnele Daley; Rocky Barilla; H Leon Pachter; Daniel Tippens; Hassan Malik; Allal Boutajangout; Thomas Wisniewski; George Miller
Journal:  PLoS One       Date:  2015-07-14       Impact factor: 3.240

5.  Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

Authors:  Erin E Congdon; Yan Lin; Hameetha B Rajamohamedsait; Dov B Shamir; Senthilkumar Krishnaswamy; Wajitha J Rajamohamedsait; Suhail Rasool; Veronica Gonzalez; Josien Levenga; Jiaping Gu; Charles Hoeffer; Einar M Sigurdsson
Journal:  Mol Neurodegener       Date:  2016-08-30       Impact factor: 14.195

6.  Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.

Authors:  Hameetha Rajamohamedsait; Suhail Rasool; Wajitha Rajamohamedsait; Yan Lin; Einar M Sigurdsson
Journal:  Sci Rep       Date:  2017-12-06       Impact factor: 4.379
  6 in total

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