Literature DB >> 22528107

A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections.

K Peter R Nilsson1, Mikael Lindgren, Per Hammarström.   

Abstract

Luminescent-conjugated oligo- and polythiophenes (LCOs and LCPs) are valuable tools for optical imaging of a plethora of protein aggregates associated with amyloidoses. Here, we describe the utilization of an anionic pentameric LCO, p-FTAA, for staining of protein aggregates in a variety of platforms, including in vitro-formed amyloid fibrils and tissue sections.

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Year:  2012        PMID: 22528107     DOI: 10.1007/978-1-61779-551-0_29

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  6 in total

Review 1.  Systemic amyloidoses.

Authors:  Luis M Blancas-Mejía; Marina Ramirez-Alvarado
Journal:  Annu Rev Biochem       Date:  2013-02-28       Impact factor: 23.643

2.  The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.

Authors:  Jack Brelstaff; Bernardino Ossola; Jonas J Neher; Therése Klingstedt; K Peter R Nilsson; Michel Goedert; Maria Grazia Spillantini; Aviva M Tolkovsky
Journal:  Front Neurosci       Date:  2015-05-29       Impact factor: 4.677

3.  Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains.

Authors:  Etheresia Pretorius; Martin J Page; Lisa Hendricks; Nondumiso B Nkosi; Sven R Benson; Douglas B Kell
Journal:  J R Soc Interface       Date:  2018-02       Impact factor: 4.118

4.  Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains.

Authors:  Etheresia Pretorius; Martin J Page; Lize Engelbrecht; Graham C Ellis; Douglas B Kell
Journal:  Cardiovasc Diabetol       Date:  2017-11-02       Impact factor: 9.951

Review 5.  To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

Authors:  Douglas B Kell; Etheresia Pretorius
Journal:  Semin Thromb Hemost       Date:  2017-08-04       Impact factor: 4.180

6.  Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.

Authors:  Shariq M Usmani; Onofrio Zirafi; Janis A Müller; Nathallie L Sandi-Monroy; Jay K Yadav; Christoph Meier; Tanja Weil; Nadia R Roan; Warner C Greene; Paul Walther; K Peter R Nilsson; Per Hammarström; Ronald Wetzel; Christopher D Pilcher; Friedrich Gagsteiger; Marcus Fändrich; Frank Kirchhoff; Jan Münch
Journal:  Nat Commun       Date:  2014-04-01       Impact factor: 14.919

  6 in total

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