| Literature DB >> 22527146 |
Murat M M Harputluoglu1, Ulvi Demirel, Mehmet Gul, Ismail Temel, Sule Gursoy, Engin Burak Selcuk, Murat Aladag, Yilmaz Bilgic, Ercan Gunduz, Yuksel Seckin.
Abstract
Intestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.Entities:
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Year: 2012 PMID： 22527146 DOI： 10.1007/s10753-012-9465-2
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092