Literature DB >> 22526312

In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis.

Lucio Vera-Cabrera1, Mayra Paola Campos-Rivera, Norma Alejandra Gonzalez-Martinez, Jorge Ocampo-Candiani, Stewart T Cole.   

Abstract

The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC(50) and MIC(90) values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis.

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Year:  2012        PMID： 22526312      PMCID： PMC3393471          DOI： 10.1128/AAC.00115-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis.

Authors:  Rokeya Tasneen; Si-Yang Li; Charles A Peloquin; Dinesh Taylor; Kathy N Williams; Koen Andries; Khisimuzi E Mdluli; Eric L Nuermberger
Journal:  Antimicrob Agents Chemother       Date:  2011-09-19       Impact factor: 5.191

2.  Construction of a Nocardia brasiliensis fluorescent plasmid to study Actinomycetoma pathogenicity.

Authors:  Mario C Salinas-Carmona; María R Rocha-Pizaña
Journal:  Plasmid       Date:  2010-09-25       Impact factor: 3.466

3.  The mechanism of action of PA-824: Novel insights from transcriptional profiling.

Authors:  Ujjini Manjunatha; Helena Im Boshoff; Clifton E Barry
Journal:  Commun Integr Biol       Date:  2009-05

4.  [Actinomycetoma and Nocardia sp. Report of five cases treated with imipenem or imipenem plus amikacin].

Authors:  Adán Fuentes; Roberto Arenas; Miguel Reyes; Ramón F Fernández; Rogelio Zacarías
Journal:  Gac Med Mex       Date:  2006 May-Jun       Impact factor: 0.302

5.  A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis.

Authors:  C K Stover; P Warrener; D R VanDevanter; D R Sherman; T M Arain; M H Langhorne; S W Anderson; J A Towell; Y Yuan; D N McMurray; B N Kreiswirth; C E Barry; W R Baker
Journal:  Nature       Date:  2000-06-22       Impact factor: 49.962

6.  Phase II dose-ranging trial of the early bactericidal activity of PA-824.

Authors:  Andreas H Diacon; Rodney Dawson; Jeannine du Bois; Kim Narunsky; Amour Venter; Peter R Donald; Christo van Niekerk; Ngozi Erondu; Ann M Ginsberg; Piet Becker; Melvin K Spigelman
Journal:  Antimicrob Agents Chemother       Date:  2012-03-19       Impact factor: 5.191

7.  Distribution of a Nocardia brasiliensis catalase gene fragment in members of the genera Nocardia, Gordona, and Rhodococcus.

Authors:  L Vera-Cabrera; W M Johnson; O Welsh; F L Resendiz-Uresti; M C Salinas-Carmona
Journal:  J Clin Microbiol       Date:  1999-06       Impact factor: 5.948

Review 8.  Mycetoma.

Authors:  Oliverio Welsh; Lucio Vera-Cabrera; Mario Cesar Salinas-Carmona
Journal:  Clin Dermatol       Date:  2007 Mar-Apr       Impact factor: 3.541

9.  In vitro activities of new antimicrobials against Nocardia brasiliensis.

Authors:  Lucio Vera-Cabrera; Eva Gonzalez; Sung H Choi; Oliverio Welsh
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

10.  PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.

Authors:  Ramandeep Singh; Ujjini Manjunatha; Helena I M Boshoff; Young Hwan Ha; Pornwaratt Niyomrattanakit; Richard Ledwidge; Cynthia S Dowd; Ill Young Lee; Pilho Kim; Liang Zhang; Sunhee Kang; Thomas H Keller; Jan Jiricek; Clifton E Barry
Journal:  Science       Date:  2008-11-28       Impact factor: 63.714
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  4 in total

1.  Towards a new combination therapy for tuberculosis with next generation benzothiazinones.

Authors:  Vadim Makarov; Benoit Lechartier; Ming Zhang; João Neres; Astrid M van der Sar; Susanne A Raadsen; Ruben C Hartkoorn; Olga B Ryabova; Anthony Vocat; Laurent A Decosterd; Nicolas Widmer; Thierry Buclin; Wilbert Bitter; Koen Andries; Florence Pojer; Paul J Dyson; Stewart T Cole
Journal:  EMBO Mol Med       Date:  2014-02-05       Impact factor: 12.137

2.  In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis.

Authors:  Norma Alejandra González-Martínez; Hector Gerardo Lozano-Garza; Jorge Castro-Garza; Alexandra De Osio-Cortez; Javier Vargas-Villarreal; Norma Cavazos-Rocha; Jorge Ocampo-Candiani; Vadim Makarov; Stewart T Cole; Lucio Vera-Cabrera
Journal:  PLoS Negl Trop Dis       Date:  2015-10-16

3.  Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis.

Authors:  Lucio Vera-Cabrera; Rocio Ortiz-Lopez; Ramiro Elizondo-Gonzalez; Jorge Ocampo-Candiani
Journal:  PLoS One       Date:  2013-06-03       Impact factor: 3.240

4.  Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity.

Authors:  Hina Bharti; Aakriti Singal; Manisha Saini; Pradeep Singh Cheema; Mohsin Raza; Suman Kundu; Alo Nag
Journal:  Sci Rep       Date:  2022-01-18       Impact factor: 4.379
  4 in total

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