Literature DB >> 2252621

Concentrations of neopterin and biopterin in the cerebrospinal fluid of patients with Parkinson's disease.

K Fujishiro1, M Hagihara, A Takahashi, T Nagatsu.   

Abstract

The concentrations of neopterin and biopterin in CSF of 18 younger and 10 older, control patients and of 18 patients with Parkinson's disease were measured by high-performance liquid chromatography with fluorescence detection. Both neopterin concentrations and the neopterin to biopterin ratios in CSF were lower in 50-year or younger group than in 51-year or older group. Biopterin concentrations were also decreased but not significantly in the older group. The concentrations of neopterin and biopterin in CSF of patients with Parkinson's disease were lower than those of the age-matched older control group. However, the neopterin/biopterin ratios tended to be lower but not change significantly as compared to the age-matched older control group.

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Year:  1990        PMID： 2252621     DOI： 10.1016/0885-4505(90)90049-7

Source DB:  PubMed          Journal:  Biochem Med Metab Biol        ISSN： 0885-4505


  7 in total

1.  Sulfamethoxazole-trimethoprim double-blind, placebo-controlled, crossover trial in Machado-Joseph disease: sulfamethoxazole-trimethoprim increases cerebrospinal fluid level of biopterin.

Authors:  T Sakai; T Matsuishi; S Yamada; H Komori; H Iwashita
Journal:  J Neural Transm Gen Sect       Date:  1995

2.  Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T).

Authors:  Shoko Koshiba; Hirofumi Tokuoka; Teruo Yokoyama; Emiko Horiuchi; Hiroshi Ichinose; Kazuko Hasegawa
Journal:  J Neural Transm (Vienna)       Date:  2011-02-03       Impact factor: 3.575

3.  Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.

Authors:  Hiroshi Ichinose; Ken-Ichi Inoue; Shinobu Arakawa; Yuki Watanabe; Hiroki Kurosaki; Shoko Koshiba; Eldbjorg Hustad; Masahiko Takada; Jan O Aasly
Journal:  J Neural Transm (Vienna)       Date:  2017-09-01       Impact factor: 3.575

Review 4.  Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease.

Authors:  Félix J Jiménez-Jiménez; Hortensia Alonso-Navarro; Elena García-Martín; José A G Agúndez
Journal:  Front Cell Neurosci       Date:  2014-11-11       Impact factor: 5.505

5.  Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture.

Authors:  Roanna J Hall; Leiv Otto Watne; Ane-Victoria Idland; Johan Raeder; Frede Frihagen; Alasdair M J MacLullich; Anne Cathrine Staff; Torgeir Bruun Wyller; Durk Fekkes
Journal:  J Neuroinflammation       Date:  2016-06-29       Impact factor: 8.322

Review 6.  What Have We Learned from Cerebrospinal Fluid Studies about Biomarkers for Detecting LRRK2 Parkinson's Disease Patients and Healthy Subjects with Parkinson's-Associated LRRK2 Mutations?

Authors:  David A Loeffler; Jan O Aasly; Peter A LeWitt; Mary P Coffey
Journal:  J Parkinsons Dis       Date:  2019       Impact factor: 5.568

7.  Genetic causes of Parkinson's disease in the Maltese: a study of selected mutations in LRRK2, MTHFR, QDPR and SPR.

Authors:  Charmaine Zahra; Christine Tabone; Graziella Camilleri; Alex E Felice; Rosienne Farrugia; Stephanie Bezzina Wettinger
Journal:  BMC Med Genet       Date:  2016-09-09       Impact factor: 2.103
  7 in total

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