Roy P C Kessels1, Pieter W Molleman, Joukje M Oosterman. 1. Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Montessorilaan 3, 6525 HR Nijmegen, The Netherlands. r.kessels@donders.ru.nl.
Abstract
BACKGROUND AND AIMS: Although episodic memory deficits are a hallmark in mild cognitive impairment (MCI) and Alzheimer's dementia (AD), little attention has been paid so far to the ability to maintain and manipulate information during a brief period of time, i.e. working memory. In this study, we examine verbal working memory in both cognitively unimpaired older people and MCI and AD patients. METHODS: Seventy- five participants were examined with either no cognitive impairment (n=25), MCI (n=25) or AD (n=25). Working memory was investigated with Wechsler's Working Memory Index tests (Digit Span, Letter-Number Sequencing and Arithmetic). RESULTS: Both MCI and AD patients performed worse on all three working-memory tests compared with controls, the subtest Letter-Number Sequencing also revealing worse performance in AD compared with MCI patients. CONCLUSIONS: Workingmemory deficits are already present in MCI patients and worsen in AD patients, suggesting that working memory should be assessed as part of neuropsychological testing.
BACKGROUND AND AIMS: Although episodic memory deficits are a hallmark in mild cognitive impairment (MCI) and Alzheimer's dementia (AD), little attention has been paid so far to the ability to maintain and manipulate information during a brief period of time, i.e. working memory. In this study, we examine verbal working memory in both cognitively unimpaired older people and MCI and ADpatients. METHODS: Seventy- five participants were examined with either no cognitive impairment (n=25), MCI (n=25) or AD (n=25). Working memory was investigated with Wechsler's Working Memory Index tests (Digit Span, Letter-Number Sequencing and Arithmetic). RESULTS: Both MCI and ADpatients performed worse on all three working-memory tests compared with controls, the subtest Letter-Number Sequencing also revealing worse performance in AD compared with MCI patients. CONCLUSIONS:Workingmemory deficits are already present in MCI patients and worsen in ADpatients, suggesting that working memory should be assessed as part of neuropsychological testing.
Authors: Annemieke M Peters van Ton; Harmke B Duindam; Julia van Tuijl; Wilson Wl Li; Hendrik-Jan Dieker; Niels P Riksen; Fj Anton Meijer; Roy Pc Kessels; Nils Kohn; Johannes G van der Hoeven; Peter Pickkers; Mark Rijpkema; Wilson F Abdo Journal: BMJ Open Date: 2021-05-11 Impact factor: 2.692
Authors: Sohae Chung; Els Fieremans; Nuri E Kucukboyaci; Xiuyuan Wang; Charles J Morton; Dmitry S Novikov; Joseph F Rath; Yvonne W Lui Journal: Sci Rep Date: 2018-02-16 Impact factor: 4.379