INTRODUCTION: To investigate the degree of the effect of aging and weight-bearing on T1rho values in normal cartilage. MATERIALS AND METHODS: Thirty-two asymptomatic patients were examined using 3.0-T magnetic resonance imaging (MRI) to determine knee cartilage T1rho values and T2 values. The femoral and tibial cartilage was divided into weight-bearing (WB-Rs) and less-weight-bearing (LWB-Rs) regions. Single regression analysis was used to assess the relationship between cartilage T1rho values and age and between T2 values and age. Analysis of variance and post hoc-testing were used to evaluate differences in WB-Rs and LWB-Rs cartilage T1rho values and T2 values. Multiple linear regression modeling was performed to predict cartilage T1rho values. RESULTS: Cartilage T1rho values correlated positively with age for all cartilage regions tested (p<0.001). There were no significant correlations between cartilage T2 values and age. In both the medial femoral and tibial cartilage, T1rho values were significantly higher in WB-Rs than in LWB-Rs (p<0.05). There were no significant differences in T2 values between WB-Rs and LWB-Rs. Multiple linear regression analysis showed that both age and weight-bearing were significant predictors of increased medial knee cartilage T1rho values (p<0.001). CONCLUSIONS: Aging and the degree of weight-bearing correlate with the change in cartilage T1rho values. Based on multiple regression modeling, aging may be a more important factor than weight-bearing for cartilage T1rho values.
INTRODUCTION: To investigate the degree of the effect of aging and weight-bearing on T1rho values in normal cartilage. MATERIALS AND METHODS: Thirty-two asymptomatic patients were examined using 3.0-T magnetic resonance imaging (MRI) to determine knee cartilage T1rho values and T2 values. The femoral and tibial cartilage was divided into weight-bearing (WB-Rs) and less-weight-bearing (LWB-Rs) regions. Single regression analysis was used to assess the relationship between cartilage T1rho values and age and between T2 values and age. Analysis of variance and post hoc-testing were used to evaluate differences in WB-Rs and LWB-Rscartilage T1rho values and T2 values. Multiple linear regression modeling was performed to predict cartilage T1rho values. RESULTS:Cartilage T1rho values correlated positively with age for all cartilage regions tested (p<0.001). There were no significant correlations between cartilage T2 values and age. In both the medial femoral and tibial cartilage, T1rho values were significantly higher in WB-Rs than in LWB-Rs (p<0.05). There were no significant differences in T2 values between WB-Rs and LWB-Rs. Multiple linear regression analysis showed that both age and weight-bearing were significant predictors of increased medial knee cartilage T1rho values (p<0.001). CONCLUSIONS: Aging and the degree of weight-bearing correlate with the change in cartilage T1rho values. Based on multiple regression modeling, aging may be a more important factor than weight-bearing for cartilage T1rho values.
Authors: Douglas R Pedersen; James A Martin; Daniel R Thedens; Noelle F Klocke; Nathaniel H Roberts; Jessica E Goetz; Annunziato Amendola Journal: Orthop Res Rev Date: 2013
Authors: Keiko Amano; Janet L Huebner; Thomas V Stabler; Matthew Tanaka; Charles E McCulloch; Iryna Lobach; Nancy E Lane; Virginia B Kraus; C Benjamin Ma; Xiaojuan Li Journal: Am J Sports Med Date: 2018-01-24 Impact factor: 6.202
Authors: Vishal Saxena; Kevin D'Aquilla; Shannon Marcoon; Guruprasad Krishnamoorthy; Joshua A Gordon; James L Carey; Ari Borthakur; J Bruce Kneeland; John D Kelly; Ravinder Reddy; Brian J Sennett Journal: Am J Sports Med Date: 2016-07-27 Impact factor: 6.202