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Literature DB >> 22525514

In vivo gene delivery by nonviral vectors: overcoming hurdles?

Yuan Zhang¹, Andrew Satterlee, Leaf Huang.

Abstract

The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and strategies to overcome these problems. We will also introduce the current progress in the design of nonviral vectors, and briefly discuss their safety issues.

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22525514 PMCID： PMC3392980 DOI： 10.1038/mt.2012.79

Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454

71 in total

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8. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice.

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92 in total

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3. Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy.

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Journal: Nano Lett Date: 2017-06-26 Impact factor: 11.189

4. Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

Authors: Johan Karlsson; Yuan Rui; Kristen L Kozielski; Amanda L Placone; Olivia Choi; Stephany Y Tzeng; Jayoung Kim; Jamal J Keyes; Max I Bogorad; Kathleen Gabrielson; Hugo Guerrero-Cazares; Alfredo Quiñones-Hinojosa; Peter C Searson; Jordan J Green
Journal: Nanoscale Date: 2019-10-15 Impact factor: 7.790