Literature DB >> 22525335

Early exposure to germs and the Hygiene Hypothesis.

Dale T Umetsu1.   

Abstract

A recent paper suggests that reduced exposure to germs results in the expansion of a cell type called natural killer T cells, which predisposes to colitis and asthma. Such a scenario could explain the Hygiene Hypothesis, which has been a puzzle for decades.

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Year:  2012        PMID： 22525335      PMCID： PMC3411171          DOI： 10.1038/cr.2012.65

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.

Authors:  Omid Akbari; Philippe Stock; Everett Meyer; Mitchell Kronenberg; Stephane Sidobre; Toshinori Nakayama; Masaru Taniguchi; Michael J Grusby; Rosemarie H DeKruyff; Dale T Umetsu
Journal:  Nat Med       Date:  2003-03-31       Impact factor: 53.440

2.  Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

Authors:  Frank Heller; Ivan J Fuss; Edward E Nieuwenhuis; Richard S Blumberg; Warren Strober
Journal:  Immunity       Date:  2002-11       Impact factor: 31.745

3.  Microbial exposure during early life has persistent effects on natural killer T cell function.

Authors:  Torsten Olszak; Dingding An; Sebastian Zeissig; Miguel Pinilla Vera; Julia Richter; Andre Franke; Jonathan N Glickman; Reiner Siebert; Rebecca M Baron; Dennis L Kasper; Richard S Blumberg
Journal:  Science       Date:  2012-03-22       Impact factor: 47.728

4.  Hay fever, hygiene, and household size.

Authors:  D P Strachan
Journal:  BMJ       Date:  1989-11-18

5.  Induction of colonic regulatory T cells by indigenous Clostridium species.

Authors:  Koji Atarashi; Takeshi Tanoue; Tatsuichiro Shima; Akemi Imaoka; Tomomi Kuwahara; Yoshika Momose; Genhong Cheng; Sho Yamasaki; Takashi Saito; Yusuke Ohba; Tadatsugu Taniguchi; Kiyoshi Takeda; Shohei Hori; Ivaylo I Ivanov; Yoshinori Umesaki; Kikuji Itoh; Kenya Honda
Journal:  Science       Date:  2010-12-23       Impact factor: 47.728

6.  Exposure to environmental microorganisms and childhood asthma.

Authors:  Markus J Ege; Melanie Mayer; Anne-Cécile Normand; Jon Genuneit; William O C M Cookson; Charlotte Braun-Fahrländer; Dick Heederik; Renaud Piarroux; Erika von Mutius
Journal:  N Engl J Med       Date:  2011-02-24       Impact factor: 91.245

7.  Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity.

Authors:  Ya-Jen Chang; Hye Young Kim; Lee A Albacker; Hyun Hee Lee; Nicole Baumgarth; Shizuo Akira; Paul B Savage; Shin Endo; Takashi Yamamura; Janneke Maaskant; Naoki Kitano; Abel Singh; Apoorva Bhatt; Gurdyal S Besra; Peter van den Elzen; Ben Appelmelk; Richard W Franck; Guangwu Chen; Rosemarie H DeKruyff; Michio Shimamura; Petr Illarionov; Dale T Umetsu
Journal:  J Clin Invest       Date:  2010-12-13       Impact factor: 14.808

8.  Induction of intestinal Th17 cells by segmented filamentous bacteria.

Authors:  Ivaylo I Ivanov; Koji Atarashi; Nicolas Manel; Eoin L Brodie; Tatsuichiro Shima; Ulas Karaoz; Dongguang Wei; Katherine C Goldfarb; Clark A Santee; Susan V Lynch; Takeshi Tanoue; Akemi Imaoka; Kikuji Itoh; Kiyoshi Takeda; Yoshinori Umesaki; Kenya Honda; Dan R Littman
Journal:  Cell       Date:  2009-10-30       Impact factor: 41.582

9.  Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals.

Authors:  Patrick J Brennan; Raju V V Tatituri; Manfred Brigl; Edy Y Kim; Amit Tuli; Joseph P Sanderson; Stephan D Gadola; Fong-Fu Hsu; Gurdyal S Besra; Michael B Brenner
Journal:  Nat Immunol       Date:  2011-10-30       Impact factor: 25.606

10.  Human CD1-restricted T cell recognition of lipids from pollens.

Authors:  Elisabetta Agea; Anna Russano; Onelia Bistoni; Roberta Mannucci; Ildo Nicoletti; Lanfranco Corazzi; Anthony D Postle; Gennaro De Libero; Steven A Porcelli; Fabrizio Spinozzi
Journal:  J Exp Med       Date:  2005-07-11       Impact factor: 14.307
  10 in total
  8 in total

1.  Gut Health in the era of the human gut microbiota: from metaphor to biovalue.

Authors:  Vincent Baty; Bruno Mougin; Catherine Dekeuwer; Gérard Carret
Journal:  Med Health Care Philos       Date:  2014-11

2.  Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice.

Authors:  Sugan Qiu; Xiaolin Fan; Yingying Yang; Panpan Dong; Wei Zhou; Yongliang Xu; Yonghua Zhou; Fukun Guo; Yi Zheng; Jun-Qi Yang
Journal:  PLoS One       Date:  2017-06-14       Impact factor: 3.240

3.  Direct-fed microbial supplementation influences the bacteria community composition of the gastrointestinal tract of pre- and post-weaned calves.

Authors:  Bridget E Fomenky; Duy N Do; Guylaine Talbot; Johanne Chiquette; Nathalie Bissonnette; Yvan P Chouinard; Martin Lessard; Eveline M Ibeagha-Awemu
Journal:  Sci Rep       Date:  2018-09-20       Impact factor: 4.379

4.  Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy.

Authors:  Daniel Munblit; Priya Abrol; Shreya Sheth; Li Yan Chow; Ekaterina Khaleva; Alan Asmanov; Silvana Lauriola; Ezio M Padovani; Pasquale Comberiati; Attilio L Boner; John O Warner; Robert J Boyle; Diego G Peroni
Journal:  Nutrients       Date:  2018-09-03       Impact factor: 5.717

5.  Effect of Multi-Microbial Probiotic Formulation Bokashi on Pro- and Anti-Inflammatory Cytokines Profile in the Serum, Colostrum and Milk of Sows, and in a Culture of Polymorphonuclear Cells Isolated from Colostrum.

Authors:  Ewa Laskowska; Łukasz Jarosz; Zbigniew Grądzki
Journal:  Probiotics Antimicrob Proteins       Date:  2019-03       Impact factor: 4.609

6.  Creatinine- and cystatin C-based estimated glomerular filtration rate slopes for the prediction of kidney outcome: a comparative retrospective study.

Authors:  Suhyun Kim; Subin Hwang; Hye Ryoun Jang; Insuk Sohn; Hyeon Seon Ahn; Hyung-Doo Park; Wooseong Huh; Dong-Chan Jin; Yoon-Goo Kim; Dae Joong Kim; Ha Young Oh; Jung Eun Lee
Journal:  BMC Nephrol       Date:  2019-06-11       Impact factor: 2.388

7.  Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding.

Authors:  Brittany V Martin-Murphy; Qiang You; Hong Wang; Becky A De La Houssaye; Timothy P Reilly; Jacob E Friedman; Cynthia Ju
Journal:  PLoS One       Date:  2014-01-20       Impact factor: 3.240

Review 8.  Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis.

Authors:  Jun-Qi Yang; Yonghua Zhou; Ram Raj Singh
Journal:  J Immunol Res       Date:  2016-08-03       Impact factor: 4.818
  8 in total

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