BACKGROUND: Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest. MATERIALS AND METHODS: On this respect, we tested the antimicrobial peptide (KLAKLAK)(2). RESULTS: This peptide exhibits cytotoxicity against human breast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo. CONCLUSION: Our data suggest a potential use of (KLAKLAK)(2) peptide for patients with breast and other types of cancer.
BACKGROUND: Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest. MATERIALS AND METHODS: On this respect, we tested the antimicrobial peptide (KLAKLAK)(2). RESULTS: This peptide exhibits cytotoxicity against humanbreast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo. CONCLUSION: Our data suggest a potential use of (KLAKLAK)(2) peptide for patients with breast and other types of cancer.
Authors: Jun Lei; Lichun Sun; Siyu Huang; Chenhong Zhu; Ping Li; Jun He; Vienna Mackey; David H Coy; Quanyong He Journal: Am J Transl Res Date: 2019-07-15 Impact factor: 4.060
Authors: Nurul Hana Zainal Baharin; Nur Fadhilah Khairil Mokhtar; Mohd Nasir Mohd Desa; Banulata Gopalsamy; Nor Nadiha Mohd Zaki; Mohd Hafis Yuswan; AbdulRahman Muthanna; Nurul Diana Dzaraly; Sahar Abbasiliasi; Amalia Mohd Hashim; Muhamad Shirwan Abdullah Sani; Shuhaimi Mustafa Journal: PeerJ Date: 2021-12-14 Impact factor: 2.984