Literature DB >> 22522742

Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform.

Yi Zou1, Swapnajit Chakravarty, Wei-Cheng Lai, Che-Yun Lin, Ray T Chen.   

Abstract

We experimentally demonstrate a method to create large-scale chip-integrated photonic crystal sensor microarrays by combining the optical power splitting characteristics of multi-mode interference (MMI) power splitters and transmission drop resonance characteristics of multiple photonic crystal microcavities arrayed along the length of the same photonic crystal waveguide. L13 photonic crystal microcavities are employed which show high Q values (~9300) in the bio-ambient phosphate buffered saline (PBS) as well as high sensitivity, experimentally demonstrated to ~98 atto-grams. Two different probe antibodies were specifically detected simultaneously with a control sample, in the same experiment.

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Year:  2012        PMID: 22522742      PMCID: PMC3417108          DOI: 10.1039/c2lc40081b

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  8 in total

1.  High-Q photonic nanocavity in a two-dimensional photonic crystal.

Authors:  Yoshihiro Akahane; Takashi Asano; Bong-Shik Song; Susumu Noda
Journal:  Nature       Date:  2003-10-30       Impact factor: 49.962

Review 2.  Protein microarrays: promising tools for proteomic research.

Authors:  Markus F Templin; Dieter Stoll; Jochen M Schwenk; Oliver Pötz; Stefan Kramer; Thomas O Joos
Journal:  Proteomics       Date:  2003-11       Impact factor: 3.984

3.  Ion detection with photonic crystal microcavities.

Authors:  S Chakravarty; J Topol'ancik; P Bhattacharya; S Chakrabarti; Y Kang; M E Meyerhoff
Journal:  Opt Lett       Date:  2005-10-01       Impact factor: 3.776

4.  Surface plasmon resonance biosensor for rapid label-free detection of microribonucleic acid at subfemtomole level.

Authors:  Hana Sípová; Shile Zhang; Aimée M Dudley; David Galas; Kai Wang; Jirí Homola
Journal:  Anal Chem       Date:  2010-11-19       Impact factor: 6.986

5.  A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips.

Authors:  C F Carlborg; K B Gylfason; A Kaźmierczak; F Dortu; M J Bañuls Polo; A Maquieira Catala; G M Kresbach; H Sohlström; T Moh; L Vivien; J Popplewell; G Ronan; C A Barrios; G Stemme; W van der Wijngaart
Journal:  Lab Chip       Date:  2009-11-12       Impact factor: 6.799

6.  Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection.

Authors:  A Densmore; M Vachon; D-X Xu; S Janz; R Ma; Y-H Li; G Lopinski; A Delâge; J Lapointe; C C Luebbert; Q Y Liu; P Cheben; J H Schmid
Journal:  Opt Lett       Date:  2009-12-01       Impact factor: 3.776

7.  Silicon nano-membrane based photonic crystal microcavities for high sensitivity bio-sensing.

Authors:  Wei-Cheng Lai; Swapnajit Chakravarty; Yi Zou; Ray T Chen
Journal:  Opt Lett       Date:  2012-04-01       Impact factor: 3.776

8.  Silicon photonic crystal nanocavity-coupled waveguides for error-corrected optical biosensing.

Authors:  Sudeshna Pal; Elisa Guillermain; Rashmi Sriram; Benjamin L Miller; Philippe M Fauchet
Journal:  Biosens Bioelectron       Date:  2011-04-02       Impact factor: 10.618

  8 in total
  9 in total

1.  The role of group index engineering in series-connected photonic crystal microcavities for high density sensor microarrays.

Authors:  Yi Zou; Swapnajit Chakravarty; Liang Zhu; Ray T Chen
Journal:  Appl Phys Lett       Date:  2014-04-08       Impact factor: 3.791

Review 2.  Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing.

Authors:  James E Baker; Rashmi Sriram; Benjamin L Miller
Journal:  Lab Chip       Date:  2015-02-21       Impact factor: 6.799

3.  Slow light enhanced sensitivity of resonance modes in photonic crystal biosensors.

Authors:  Wei-Cheng Lai; Swapnajit Chakravarty; Yi Zou; Yunbo Guo; Ray T Chen
Journal:  Appl Phys Lett       Date:  2013-01-29       Impact factor: 3.791

4.  Silicon on-chip bandpass filters for the multiplexing of high sensitivity photonic crystal microcavity biosensors.

Authors:  Hai Yan; Yi Zou; Swapnajit Chakravarty; Chun-Ju Yang; Zheng Wang; Naimei Tang; Donglei Fan; Ray T Chen
Journal:  Appl Phys Lett       Date:  2015-03-23       Impact factor: 3.791

5.  Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors.

Authors:  Swapnajit Chakravarty; Wei-Cheng Lai; Yi Zou; Harry A Drabkin; Robert M Gemmill; George R Simon; Steve H Chin; Ray T Chen
Journal:  Biosens Bioelectron       Date:  2012-11-27       Impact factor: 10.618

6.  Recognition-mediated particle detection under microfluidic flow with waveguide-coupled 2D photonic crystals: towards integrated photonic virus detectors.

Authors:  James E Baker; Rashmi Sriram; Benjamin L Miller
Journal:  Lab Chip       Date:  2017-05-02       Impact factor: 6.799

7.  Design low crosstalk ring-slot array structure for label-free multiplexed sensing.

Authors:  Lijun Huang; Huiping Tian; Jian Zhou; Yuefeng Ji
Journal:  Sensors (Basel)       Date:  2014-08-25       Impact factor: 3.576

8.  Recent advances in integrated photonic sensors.

Authors:  Vittorio M N Passaro; Corrado de Tullio; Benedetto Troia; Mario La Notte; Giovanni Giannoccaro; Francesco De Leonardis
Journal:  Sensors (Basel)       Date:  2012-11-09       Impact factor: 3.576

Review 9.  Dual-Mode Electro-Optical Techniques for Biosensing Applications: A Review.

Authors:  José Juan-Colás; Steven Johnson; Thomas F Krauss
Journal:  Sensors (Basel)       Date:  2017-09-07       Impact factor: 3.576

  9 in total

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