| Literature DB >> 22522568 |
Y Fløisand1, L Brinch, T Gedde-Dahl, G E Tjønnfjord, I Dybedal, H Holte, D Heldal, D Torfoss, E Aurlien, G F Lauritzsen, A Fosså, G Lehne, E Baggerød, G Kvalheim, T Egeland, M R Bishop, D H Fowler, A Kolstad.
Abstract
Reduced-intensity conditioning (RIC) allo-SCT is a potentially curative treatment approach for patients with relapsed Hodgkin's or non-Hodgkin's lymphoma. In the present study, 37 patients underwent RIC allo-SCT after induction treatment with EPOCH-F(R) using a novel form of dual-agent immunosuppression for GVHD prophylaxis with CsA and sirolimus. With a median follow-up of 28 months among survivors, the probability for OS at 3 and 5 years was 56%. Treatment-related mortality was 16% at day +100 and 30% after 1 year of transplant. Acute GVHD grades II-IV developed in 38% of patients, suggesting that the regimen consisting of CsA and an ultra-short course of sirolimus is effective in the prevention of acute GVHD.Entities:
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Year: 2012 PMID： 22522568 PMCID： PMC6980358 DOI： 10.1038/bmt.2012.63
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483