Literature DB >> 2252163

Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma.

L Hasselmark1, R Malmgren, G Unge, O Zetterström.   

Abstract

Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0 +/- 7.1 U/10(11) platelets, which is significantly lower than that of 56.4 +/- 12 U/10(11) platelets in the controls (P less than 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2252163     DOI： 10.1111/j.1398-9995.1990.tb00528.x

Source DB:  PubMed          Journal:  Allergy        ISSN： 0105-4538            Impact factor:   13.146


  12 in total

Review 1.  Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities.

Authors:  Anne M Fitzpatrick; Dean P Jones; Lou Ann S Brown
Journal:  Antioxid Redox Signal       Date:  2012-03-09       Impact factor: 8.401

Review 2.  The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities.

Authors:  Zhi Huang; Aaron H Rose; Peter R Hoffmann
Journal:  Antioxid Redox Signal       Date:  2012-01-09       Impact factor: 8.401

Review 3.  Controversial forms of treatment for asthma.

Authors:  P Chanez; J Bousquet; P Godard; F B Michel
Journal:  Clin Rev Allergy Immunol       Date:  1996       Impact factor: 8.667

4.  Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation.

Authors:  Susanne R Youngren; Rohit Mulik; Byoung Jun; Peter R Hoffmann; Kenneth R Morris; Mahavir B Chougule
Journal:  AAPS PharmSciTech       Date:  2013-09       Impact factor: 3.246

Review 5.  Selenium and asthma.

Authors:  Robert L Norton; Peter R Hoffmann
Journal:  Mol Aspects Med       Date:  2011-10-15

6.  In vitro release of arachidonic acid metabolites, glutathione peroxidase, and oxygen-free radicals from platelets of asthmatic patients with and without aspirin intolerance.

Authors:  V Plaza; J Prat; J Rosellò; E Ballester; I Ramis; J Mullol; E Gelpí; J L Vives-Corrons; C Picado
Journal:  Thorax       Date:  1995-05       Impact factor: 9.139

7.  Selenium status is decreased in patients with intrinsic asthma.

Authors:  J Kadrabová; A Mad'aric; Z Kovaciková; F Podivínsky; E Ginter; F Gazdík
Journal:  Biol Trace Elem Res       Date:  1996-06       Impact factor: 3.738

8.  Grape seed proanthocyanidin extract attenuates allergic inflammation in murine models of asthma.

Authors:  Taehoon Lee; Hyouk-Soo Kwon; Bo-Ram Bang; Yoon Su Lee; Mi-Young Park; Keun-Ai Moon; Tae-Bum Kim; Ki-Young Lee; Hee-Bom Moon; You Sook Cho
Journal:  J Clin Immunol       Date:  2012-07-27       Impact factor: 8.317

Review 9.  Selenium supplementation for asthma.

Authors:  M F Allam; R A Lucane
Journal:  Cochrane Database Syst Rev       Date:  2004

10.  A multivariate analysis of serum nutrient levels and lung function.

Authors:  Tricia M McKeever; Sarah A Lewis; Henriette A Smit; Peter Burney; Patricia A Cassano; John Britton
Journal:  Respir Res       Date:  2008-09-29
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.