Literature DB >> 22521571

The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.

K M Fyall1, A M Fong, S B Rao, J G Ibrahim, W T Waxweiler, N E Thomas.   

Abstract

T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human lymphocytes from healthy participants.
Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22521571      PMCID： PMC3368090          DOI： 10.1016/j.humimm.2012.03.005

Source DB:  PubMed          Journal:  Hum Immunol        ISSN： 0198-8859            Impact factor:   2.850


  15 in total

1.  A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.

Authors:  J-R Li; J-G Li; G-H Deng; W-L Zhao; Y-J Dan; Y-M Wang; S Chen
Journal:  Scand J Immunol       Date:  2011-05       Impact factor: 3.487

2.  Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.

Authors:  Song Chen; Wenli Zhao; Wenting Tan; Xiao Luo; Yunjie Dan; Zhonglan You; Xuemei Kuang; Yuming Wang; Guohong Deng
Journal:  Hum Immunol       Date:  2010-10-25       Impact factor: 2.850

3.  TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.

Authors:  Kathrin Suttner; Philip Rosenstiel; Martin Depner; Michaela Schedel; Leonardo A Pinto; Andreas Ruether; Jerzy Adamski; Norman Klopp; Thomas Illig; Christian Vogelberg; Stefan Schreiber; Erika von Mutius; Michael Kabesch
Journal:  J Allergy Clin Immunol       Date:  2009-04-10       Impact factor: 10.793

Review 4.  T-bet in disease.

Authors:  Vanja Lazarevic; Laurie H Glimcher
Journal:  Nat Immunol       Date:  2011-06-20       Impact factor: 25.606

5.  Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production.

Authors:  Brandon M Sullivan; Ousman Jobe; Vanja Lazarevic; Kristine Vasquez; Roderick Bronson; Laurie H Glimcher; Igor Kramnik
Journal:  J Immunol       Date:  2005-10-01       Impact factor: 5.422

6.  Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus.

Authors:  Y You; W Zhao; S Chen; W Tan; Y Dan; F Hao; G Deng
Journal:  Scand J Rheumatol       Date:  2010-05       Impact factor: 3.641

7.  Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.

Authors:  Mitsuteru Akahoshi; Kazuhiko Obara; Tomomitsu Hirota; Akira Matsuda; Koichi Hasegawa; Naomi Takahashi; Makiko Shimizu; Kazuko Nakashima; Lei Cheng; Satoru Doi; Hiroshi Fujiwara; Akihiko Miyatake; Kimie Fujita; Noritaka Higashi; Masami Taniguchi; Tadao Enomoto; Xiao-Quan Mao; Hitoshi Nakashima; Chaker N Adra; Yusuke Nakamura; Mayumi Tamari; Taro Shirakawa
Journal:  Hum Genet       Date:  2005-04-02       Impact factor: 4.132

8.  Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Authors:  Susanne J Szabo; Brandon M Sullivan; Claudia Stemmann; Abhay R Satoskar; Barry P Sleckman; Laurie H Glimcher
Journal:  Science       Date:  2002-01-11       Impact factor: 47.728

9.  Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.

Authors:  Pravitt Gourh; Sandeep K Agarwal; Dipal Divecha; Shervin Assassi; Gene Paz; Rajpreet K Arora-Singh; John D Reveille; Sanjay Shete; Maureen D Mayes; Frank C Arnett; Filemon K Tan
Journal:  Arthritis Rheum       Date:  2009-12

10.  A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in humans.

Authors:  Alexandra Svensson; Ann-Marie H Bergin; Gun-Britt Löwhagen; Petra Tunbäck; Lars Bellner; Leonid Padyukov; Kristina Eriksson
Journal:  J Gen Virol       Date:  2008-09       Impact factor: 3.891
View more
  3 in total

1.  TBX21 polymorphisms are associated with virus persistence in hepatitis C virus infection patients from a high-risk Chinese population.

Authors:  D Y Zhu; L F Jiang; X Z Deng; W Xiao; J P Pei; B J Li; C J Wang; J H Zhang; Q Zhang; Z X Zhou; W L Ding; X D Xu; M Yue
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-03-11       Impact factor: 3.267

2.  Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population.

Authors:  Rui-Xue Leng; Hai-Feng Pan; Juan Liu; Xiao-Ke Yang; Chao Zhang; Sha-Sha Tao; De-Guang Wang; Xiao-Mei Li; Xiang-Pei Li; Wanling Yang; Dong-Qing Ye
Journal:  Sci Rep       Date:  2016-02-26       Impact factor: 4.379

3.  Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.

Authors:  Wei Sun; Hong-Yan Wu; Song Chen
Journal:  World J Gastroenterol       Date:  2017-12-28       Impact factor: 5.742
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.