OBJECTIVE: Carbon monoxide (CO) in cigarette smoke may be the mechanism by which tobacco use during pregnancy decreases the risk of the development of preeclampsia. We attempted to test this hypothesis by examining the effect of maternal exposure to ambient CO on preeclampsia. STUDY DESIGN: Births that occurred between 2004 and 2009 in the Canadian province of Ontario were extracted from the data. Study subjects were divided into 4 groups according to quartiles of CO concentration that were based on maternal residence. Adjusted odds ratio and 95% confidence interval were used to estimate the independent effect of CO on preeclampsia. RESULTS: Rates of preeclampsia were 2.32%, 1.97%, 1.59%, and 1.26%, respectively, in the first, second, third, and fourth quartile of CO concentration. The inverse association between CO concentration and preeclampsia risk remained the same after adjustment for several important confounding factors. CONCLUSION: Maternal exposure to moderate ambient CO is associated independently with a decreased risk of preeclampsia. Crown
OBJECTIVE:Carbon monoxide (CO) in cigarette smoke may be the mechanism by which tobacco use during pregnancy decreases the risk of the development of preeclampsia. We attempted to test this hypothesis by examining the effect of maternal exposure to ambient CO on preeclampsia. STUDY DESIGN: Births that occurred between 2004 and 2009 in the Canadian province of Ontario were extracted from the data. Study subjects were divided into 4 groups according to quartiles of CO concentration that were based on maternal residence. Adjusted odds ratio and 95% confidence interval were used to estimate the independent effect of CO on preeclampsia. RESULTS: Rates of preeclampsia were 2.32%, 1.97%, 1.59%, and 1.26%, respectively, in the first, second, third, and fourth quartile of CO concentration. The inverse association between CO concentration and preeclampsia risk remained the same after adjustment for several important confounding factors. CONCLUSION: Maternal exposure to moderate ambient CO is associated independently with a decreased risk of preeclampsia. Crown
Authors: Daniel M Kraus; Liping Feng; R Phillips Heine; Haywood L Brown; Kathleen M Caron; Amy P Murtha; Chad A Grotegut Journal: Reprod Sci Date: 2013-05-07 Impact factor: 3.060
Authors: Patricia D Koman; Kelly A Hogan; Natalie Sampson; Rebecca Mandell; Chris M Coombe; Myra M Tetteh; Yolanda R Hill-Ashford; Donele Wilkins; Marya G Zlatnik; Rita Loch-Caruso; Amy J Schulz; Tracey J Woodruff Journal: World Med Health Policy Date: 2018-03-12
Authors: Eric M George; Junie P Warrington; Frank T Spradley; Ana C Palei; Joey P Granger Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-06-04 Impact factor: 3.619
Authors: Rong Yang; Dan Luo; Yi-Ming Zhang; Ke Hu; Zheng-Min Qian; Li-Qin Hu; Long-Jiao Shen; Hong Xian; Juliet Iwelunmor; Su-Rong Mei Journal: Curr Med Sci Date: 2019-12-16