Literature DB >> 22520261

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

Li-Jun Wang1, Chang-An Geng, Yun-Bao Ma, Xiao-Yan Huang, Jie Luo, Hao Chen, Xue-Mei Zhang, Ji-Jun Chen.   

Abstract

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC(50) values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22520261     DOI： 10.1016/j.bmcl.2012.03.081

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

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8.  Comparative studies on the properties of glycyrrhetinic acid-loaded PLGA microparticles prepared by emulsion and template methods.

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Authors:  Bing Xu; Gao-Rong Wu; Xin-Yu Zhang; Meng-Meng Yan; Rui Zhao; Nan-Nan Xue; Kang Fang; Hui Wang; Meng Chen; Wen-Bo Guo; Peng-Long Wang; Hai-Min Lei
Journal:  Molecules       Date:  2017-06-02       Impact factor: 4.411
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