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Literature DB >> 225195

Possible mechanism of rubidium-induced hyperactivity in the rat.

Abstract

This study suggests that replacement of intracellular potassium by rubidium ions might lower the resting membrane potential. Thus rubidium-treated rats were more responsive to depolarizing influences and generated more cyclic AMP in the brainstem and consequently the behavioral changes.

Entities: Chemical Disease Species

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Year: 1979 PMID： 225195 DOI： 10.1007/bf01949960

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

14 in total

1. The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons.

Authors: P F BAKER; A L HODGKIN; T I SHAW
Journal: J Physiol Date: 1962-11 Impact factor: 5.182

2. Cyclic nucleotdides in the central synaptic actions of catecholamines.

Authors: F E Bloom; G R Siggins; B J Hoffer; M Segal; A P Oliver
Journal: Adv Cyclic Nucleotide Res Date: 1975

3. Effects of alkali metal chlorides on activity in rats.

Authors: F N Johnson
Journal: Nature Date: 1972-08-11 Impact factor: 49.962

4. Cyclic AMP in brain areas: effects of amphetamine and norepinephrine assessed through the use of microwave radiation as a means of tissue fixation.

Authors: M J Schmidt; J T Hopkins; D E Schmidt; G A Robison
Journal: Brain Res Date: 1972-07-20 Impact factor: 3.252

5. Determination of adenosine 3':5'-cyclic monophosphate in cerebral tissues by saturation analysis. Assessment of a method using a binding protein from ox muscle.

Authors: M Weller; R Rodnight; D Carrera
Journal: Biochem J Date: 1972-08 Impact factor: 3.857

Possible mechanism of rubidium-induced hyperactivity in the rat.

1. The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons.

2. Cyclic nucleotdides in the central synaptic actions of catecholamines.

3. Effects of alkali metal chlorides on activity in rats.

4. Cyclic AMP in brain areas: effects of amphetamine and norepinephrine assessed through the use of microwave radiation as a means of tissue fixation.

5. Determination of adenosine 3':5'-cyclic monophosphate in cerebral tissues by saturation analysis. Assessment of a method using a binding protein from ox muscle.

6. Rubidium: biochemical, behavioral, and metabolic studies in humans.

7. Rubidium: a potential modifier of affect and behaviour.

8. Brain norepinephrine: enhanced turnover after rubidium treatment.

9. Cyclic adenosine monophosphate in brain areas: microwave irradiation as a means of tissue fixation.

10. Effects of rubidium chloride on the course of manic-depressive illness.