Literature DB >> 22519425

Memory impairment exhibited by veterans with Gulf War Illness.

Timothy N Odegard1, Crystal M Cooper, Emily A Farris, Josh Arduengo, James Bartlett, Robert Haley.   

Abstract

Roughly 26-32% of US veterans, who served in the first Gulf War, report suffering from chronic health problems ( Golomb, 2008 , Proceedings of the National Academies of Science, 105, 4295). The present study investigated the memory deficits reported by these ill Gulf War veterans (GWV) using a face-name associative memory paradigm administered during functional magnetic resonance imaging (fMRI). The fMRI data confirmed memory performance on the memory task to be related to the amount of activation in the left hippocampus observed during the study. In addition, ill-GWV demonstrated decreased memory performance relative to unaffected GWV on this memory test, providing evidence of memory deficits using an objective measure of memory.

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Year:  2012        PMID: 22519425     DOI: 10.1080/13554794.2012.667126

Source DB:  PubMed          Journal:  Neurocase        ISSN: 1355-4794            Impact factor:   0.881


  17 in total

1.  Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus.

Authors:  Vipan K Parihar; Bharathi Hattiangady; Bing Shuai; Ashok K Shetty
Journal:  Neuropsychopharmacology       Date:  2013-06-28       Impact factor: 7.853

Review 2.  Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication.

Authors:  Laxmikant S Deshpande; Robert E Blair; Kristin F Phillips; Robert J DeLorenzo
Journal:  Ann N Y Acad Sci       Date:  2016-06-21       Impact factor: 5.691

3.  Central Executive Dysfunction and Deferred Prefrontal Processing in Veterans with Gulf War Illness.

Authors:  Nicholas A Hubbard; Joanna L Hutchison; Michael A Motes; Ehsan Shokri-Kojori; Ilana J Bennett; Ryan M Brigante; Robert W Haley; Bart Rypma
Journal:  Clin Psychol Sci       Date:  2014-05-01

4.  Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus.

Authors:  M Kodali; B Hattiangady; G A Shetty; A Bates; B Shuai; A K Shetty
Journal:  Brain Behav Immun       Date:  2018-02-15       Impact factor: 7.217

Review 5.  Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.

Authors:  Brandon Dickey; Leelavathi N Madhu; Ashok K Shetty
Journal:  Pharmacol Ther       Date:  2020-10-24       Impact factor: 12.310

6.  Vagus Nerve Stimulation Ameliorates Cognitive Impairment and Increased Hippocampal Astrocytes in a Mouse Model of Gulf War Illness.

Authors:  Lavanya Venkatasamy; Damir Nizamutdinov; Jaclyn Jenkins; Lee A Shapiro
Journal:  Neurosci Insights       Date:  2021-05-28

7.  Exercise challenge in Gulf War Illness reveals two subgroups with altered brain structure and function.

Authors:  Rakib U Rayhan; Benson W Stevens; Megna P Raksit; Joshua A Ripple; Christian R Timbol; Oluwatoyin Adewuyi; John W VanMeter; James N Baraniuk
Journal:  PLoS One       Date:  2013-06-14       Impact factor: 3.240

8.  Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness.

Authors:  Bharathi Hattiangady; Vikas Mishra; Maheedhar Kodali; Bing Shuai; Xiolan Rao; Ashok K Shetty
Journal:  Front Behav Neurosci       Date:  2014-03-13       Impact factor: 3.558

9.  Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness.

Authors:  Tarick Megahed; Bharathi Hattiangady; Bing Shuai; Ashok K Shetty
Journal:  Front Cell Neurosci       Date:  2015-01-08       Impact factor: 5.505

10.  Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice.

Authors:  Carla Garza-Lombó; Morrent Thang; Hendrik J Greve; Christen L Mumaw; Evan J Messenger; Chandrama Ahmed; Emily Quinn; Kimberly Sullivan; Michelle L Block
Journal:  Transl Psychiatry       Date:  2021-07-12       Impact factor: 6.222

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