Literature DB >> 22519394

Some recent approaches of biologically active substituted pyridazine and phthalazine drugs.

M Asif1.   

Abstract

Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and phthalazines are important structural feature of many biologically active compounds and show diverse pharmacological properties. Pyridazines and phthalazines hold considerable interest relative to the preparation of organic intermediates and physiologically active compounds. On the basis of literature, pyridazines, pyridazinone and phthalazines further focus our attention because of their easy fictionalization at various ring positions, which makes them attractive synthetic compounds for designing and development of the novel pyridazines and phthalazines drugs in future.

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Year:  2012        PMID: 22519394     DOI: 10.2174/092986712800672139

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN: 0929-8673            Impact factor:   4.530


  12 in total

1.  Photophysical Properties of a Novel and Biologically Active 3(2H)-Pyridazinone Derivative Using Solvatochromic Approach.

Authors:  Vani R Desai; Shirajahammad M Hunagund; Malatesh S Pujar; Mahantesha Basanagouda; Jagadish S Kadadevarmath; Ashok H Sidarai
Journal:  J Fluoresc       Date:  2017-06-05       Impact factor: 2.217

2.  Analysis of Fluorescence Quenching for Newly Synthesized Biologically Active 3(2H)-pyridazinone Derivative by Aniline.

Authors:  Vani R Desai; Shirajahammad M Hunagund; Mahantesha Basanagouda; Jagadish S Kadadevarmath; Ashok H Sidarai
Journal:  J Fluoresc       Date:  2017-05-31       Impact factor: 2.217

3.  The influence of oxo-bridged binuclear gold(III) complexes on Na/K-ATPase activity: a joint experimental and theoretical approach.

Authors:  Aleksandra M Bondžić; Mirjana B Čolović; Goran V Janjić; Božidarka Zarić; Sandra Petrović; Danijela Z Krstić; Tiziano Marzo; Luigi Messori; Vesna M Vasić
Journal:  J Biol Inorg Chem       Date:  2017-04-21       Impact factor: 3.358

4.  Solvent Effects on the Electronic Absorption and Fluorescence Spectra of HNP: Estimation of Ground and Excited State Dipole Moments.

Authors:  Vani R Desai; Shirajahammad M Hunagund; Mahantesha Basanagouda; Jagadish S Kadadevarmath; Ashok H Sidarai
Journal:  J Fluoresc       Date:  2016-05-25       Impact factor: 2.217

5.  A Hyperpolarizable 1 H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage.

Authors:  Soumya S Roy; Philip Norcott; Peter J Rayner; Gary G R Green; Simon B Duckett
Journal:  Angew Chem Int Ed Engl       Date:  2016-11-15       Impact factor: 15.336

6.  A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes.

Authors:  Soumya S Roy; Philip Norcott; Peter J Rayner; Gary G R Green; Simon B Duckett
Journal:  Chemistry       Date:  2017-07-19       Impact factor: 5.236

7.  A simple and cost-efficient technique to generate hyperpolarized long-lived 15N-15N nuclear spin order in a diazine by signal amplification by reversible exchange.

Authors:  Soumya S Roy; Peter J Rayner; Michael J Burns; Simon B Duckett
Journal:  J Chem Phys       Date:  2020-01-07       Impact factor: 3.488

8.  Visible light amination/Smiles cascade: access to phthalazine derivatives.

Authors:  Etienne Brachet; Leyre Marzo; Mohamed Selkti; Burkhard König; Philippe Belmont
Journal:  Chem Sci       Date:  2016-05-06       Impact factor: 9.825

9.  Design of Angiotensin-converting Enzyme 2 (ACE2) Inhibitors by Virtual Lead Optimization and Screening.

Authors:  Juan E Torres; Rosa Baldiris; Ricardo Vivas-Reyes
Journal:  J Chin Chem Soc       Date:  2012-07-23       Impact factor: 1.967

10.  Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives by the Reaction of Malononitrile, Aldehydes and 2-Oxoglyoxalarylhydrazones in Q-Tubes.

Authors:  Majdah A Al-Johani; Khadijah M Al-Zaydi; Sameera M Mousally; Norah F Alqahtani; Noha Hilmy Elnagdi; Mohamed H Elnagdi
Journal:  Molecules       Date:  2017-12-01       Impact factor: 4.411

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