BACKGROUND: Stem cell therapy for stroke is in its initial stages as an option to restore lost neurological functions after stroke. OBJECTIVE: To provide a comprehensive review of studies involving stem cells in stroke treatment and to highlight new evidence from the ongoing clinical trials. METHODOLOGY: We performed a systematic study of various published journals in online medical libraries using Pubmed, Sciencedirect, and hajournal. Evidence synthesis is done with specific search words of - stem cell therapy, stroke, trophic factor, neural progenitor cell, pathophysiology, mechanism of action, clinical trial and mesenchymal stem cell in various combinations. Emphasis was given to articles published in year 2000 and onwards. RESULTS: Current research on stem cell therapy for stroke focuses on transplantation and endogenous neurogenesis of stem cells in brain. The sub-ventricular zone in the adult brain is identified as an endogenous resource of neuronal precursors that can be recruited to adjacent lesioned areas. Several factors can increase adult neurogenesis by stimulating formation or improving survival of new neurons, such as FGF-2, EGF, stem cell factor, erythropoietin, BDNF, caspase inhibitors, and anti-inflammatory drugs. Much of the beneficial effects of stem cell in stroke models are related to secretion of trophic factors. CONCLUSION: The complex pathophysiology involving various trophic factors, growth factor and gene modification in animal studies have showed promising result. Future research involving these trophic factors should open up new additional or clinically significant alternative for the treatment of stroke.
BACKGROUND: Stem cell therapy for stroke is in its initial stages as an option to restore lost neurological functions after stroke. OBJECTIVE: To provide a comprehensive review of studies involving stem cells in stroke treatment and to highlight new evidence from the ongoing clinical trials. METHODOLOGY: We performed a systematic study of various published journals in online medical libraries using Pubmed, Sciencedirect, and hajournal. Evidence synthesis is done with specific search words of - stem cell therapy, stroke, trophic factor, neural progenitor cell, pathophysiology, mechanism of action, clinical trial and mesenchymal stem cell in various combinations. Emphasis was given to articles published in year 2000 and onwards. RESULTS: Current research on stem cell therapy for stroke focuses on transplantation and endogenous neurogenesis of stem cells in brain. The sub-ventricular zone in the adult brain is identified as an endogenous resource of neuronal precursors that can be recruited to adjacent lesioned areas. Several factors can increase adult neurogenesis by stimulating formation or improving survival of new neurons, such as FGF-2, EGF, stem cell factor, erythropoietin, BDNF, caspase inhibitors, and anti-inflammatory drugs. Much of the beneficial effects of stem cell in stroke models are related to secretion of trophic factors. CONCLUSION: The complex pathophysiology involving various trophic factors, growth factor and gene modification in animal studies have showed promising result. Future research involving these trophic factors should open up new additional or clinically significant alternative for the treatment of stroke.
Authors: Nicole Casadevall; Joelle Nataf; Beatrice Viron; Amir Kolta; Jean-Jacques Kiladjian; Philippe Martin-Dupont; Patrick Michaud; Thomas Papo; Valerie Ugo; Irene Teyssandier; Bruno Varet; Patrick Mayeux Journal: N Engl J Med Date: 2002-02-14 Impact factor: 91.245
Authors: H H Marti; R H Wenger; L A Rivas; U Straumann; M Digicaylioglu; V Henn; Y Yonekawa; C Bauer; M Gassmann Journal: Eur J Neurosci Date: 1996-04 Impact factor: 3.386
Authors: Alison E Willing; Martina Vendrame; Jennifer Mallery; C Jordan Cassady; Cyndy D Davis; Juan Sanchez-Ramos; Paul R Sanberg Journal: Cell Transplant Date: 2003 Impact factor: 4.064
Authors: I M Carvalho; P B Coelho; P C Costa; C S Marques; R S Oliveira; D C Ferreira Journal: Neuromolecular Med Date: 2015-09-15 Impact factor: 3.843
Authors: Jie Zhang; Yunyao Jiang; Nan Liu; Ting Shen; Hyo Won Jung; Jianxun Liu; Bing Chun Yan Journal: Front Neurol Date: 2019-12-19 Impact factor: 4.003